Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3574
Official Symbol:IL7
Other Aliases:IL-7
See related:HGNC:6023|MIM:146660|HPRD:00892
Chromosome:8
Location:8q12-q13
Gene Description:interleukin 7
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0213
ORGANISM:human
Entrez Gene ID:3574
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Downregulated
Fold Change:At least 2-folds difference
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
16196CBCerebellum1.979866623878483.84741520881653
16196CTXCerebral cortex0.6050605773925780.856369853019714
16196HIPHippocampal region0.3074038326740260.506838440895081
16196HPFHippocampal formation0.3041949868202210.444454103708267
16196HYHypothalamus0.9250054359436040.83769017457962
16196LSXLateral septal complex0.2465437054634090.164895430207253
16196MBMidbrain1.860561847686772.71066498756409
16196MYMedulla1.949696660041812.68392300605774
16196OLFOlfactory bulb0.5108435153961180.514714956283569
16196PPons0.459881305694580.639080047607422
16196PALPallidum0.1180465891957280.066509872674942
16196RHPRetrohippocampal region0.2912467122077940.360732227563858
16196sAMYStriatum-like amygdalar nuclei0.5032714605331420.423224240541458
16196STRStriatum0.2647636830806730.273522198200226
16196STRdStriatum dorsal region0.226593703031540.278829127550125
16196STRvStriatum ventral region0.1961282342672350.133722350001335
16196THThalamus2.857364416122444.46083164215088
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3574GO:0005139IEAFunctioninterleukin-7 receptor binding
3574GO:0005139TASFunctioninterleukin-7 receptor binding
3574GO:0005515IPIFunctionprotein binding
3574GO:0005576IEAComponentextracellular region
3574GO:0005615IEAComponentextracellular space
3574GO:0006955IEAProcessimmune response
3574GO:0006959TASProcesshumoral immune response
3574GO:0007267TASProcesscell-cell signaling
3574GO:0008284TASProcesspositive regulation of cell proliferation
3574GO:0009887TASProcessorgan morphogenesis
3574GO:0030890ISSProcesspositive regulation of B cell proliferation
3574GO:0043066ISSProcessnegative regulation of apoptosis
3574GO:0045453ISSProcessbone resorption
3574GO:0045582ISSProcesspositive regulation of T cell differentiation
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3575NP_002176.1interleukin 7 receptorHPRD00893
NP_000871.1---BIND183074
NP_000871.13575-Interleukin 7 receptorHPRD00892
NP_000871.13575NP_002176.2interleukin 7 receptor precursorBIND182963
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3574IL7_HUMANP13232IPR000226Interleukin_7_9Interleukin-7/interleukin-9
3574IL7_HUMANP13232IPR001181Interleukin-7Interleukin-7

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