Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3587
Official Symbol:IL10RA
Other Aliases:CDW210A|HIL-10R|IL-10R1|IL10R
See related:HGNC:5964|MIM:146933|HPRD:00911
Chromosome:11
Location:11q23
Gene Description:interleukin 10 receptor, alpha
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0412
ORGANISM:human
Entrez Gene ID:3587
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.9 :: -1.9 :: -1.4 :: -1.3
KARG Evidence 2
KARG ID:EVIM0480
ORGANISM:human
Entrez Gene ID:3587
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1.5 :: -1 :: 1 :: -1.3 :: -1.3
KARG Evidence 3
KARG ID:QTL0133
ORGANISM:human
Entrez Gene ID:3587
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
16154CBCerebellum1.269966244697571.36821377277374
16154CTXCerebral cortex1.668506979942321.44715178012848
16154HIPHippocampal region0.9035320580005650.824076265096664
16154HPFHippocampal formation1.147433459758760.747905522584915
16154HYHypothalamus0.7327979654073720.59405380487442
16154LSXLateral septal complex0.9433309733867650.895093739032745
16154MBMidbrain0.9004592299461360.750071614980698
16154MYMedulla2.551763772964482.78471618890762
16154OLFOlfactory bulb1.548895269632340.860486045479774
16154PPons1.227789640426640.941391229629517
16154PALPallidum0.510026119649410.296116732060909
16154RHPRetrohippocampal region1.565586775541310.677895724773407
16154sAMYStriatum-like amygdalar nuclei1.035910062491890.500470466911793
16154STRStriatum0.8141694962978360.548338353633881
16154STRdStriatum dorsal region0.7076457589864730.488252654671669
16154STRvStriatum ventral region0.8272584825754170.390656407922506
16154THThalamus0.7776855826377870.702072307467461
KARG Evidence 4
KARG ID:HOT0221
Entrez Gene ID:3587
RefSeq ID:NM_001558
Position Information:+, Enhancer, 43793bp
Linkage Marker:D11S976
Evidence Type:LINKAGE-BASED (SINGLE POINT)
Evidence Name:PUBMED
Evidence ID:9603607
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
KARG Evidence 5
KARG ID:QTL0133
Trait:alcohol preference
Peak:26
Peak Marker:D9Mit330
Parents:(C57BL/6J x DBA/2J)F2 intercross
Evidence ID:9726281
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3587GO:0004872TASFunctionreceptor activity
3587GO:0004896IEAFunctionhematopoietin/interferon-class (D200-domain) cytokine receptor activity
3587GO:0004920TASFunctioninterleukin-10 receptor activity
3587GO:0005886TASComponentplasma membrane
3587GO:0016021IEAComponentintegral to membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3716NP_002218.1janus kinase 1HPRD00992
NP_001549.1--Interleukin 10 like proteinHPRD00911
NP_001549.13716-Janus kinase 1HPRD00911
NP_001549.13588NP_000619.3interleukin 10 receptor, beta precursorHPRD00473
NP_001549.13588NP_000619.3interleukin 10 receptor, beta precursorHPRD00911
NP_001549.13716NP_002218.1janus kinase 1BIND183012
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3587I10R1_HUMANQ13651IPR000282Cytok_rcpt_2Cytokine receptor class 2

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