Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3603
Official Symbol:IL16
Other Aliases:FLJ16806|FLJ42735|FLJ44234|HsT19289|IL-16|LCF|prIL-16
See related:HGNC:5980|MIM:603035|HPRD:04329
Chromosome:15
Location:15q26.3
Gene Description:interleukin 16 (lymphocyte chemoattractant factor)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIL0275
ORGANISM:human
Entrez Gene ID:3603
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:14741421
Addiction Drug:
Addiction Drug Detail:Substance abuse manifest increased IL-16 expression
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
16170CBCerebellum91.7203979492188100.0
16170CTXCerebral cortex1.996537506580351.89717656373978
16170HIPHippocampal region28.250687599182146.5536727905273
16170HPFHippocampal formation19.542400360107429.0185966491699
16170HYHypothalamus1.22840952873231.4173492193222
16170LSXLateral septal complex0.4589753001928330.569225162267685
16170MBMidbrain0.6949080526828771.16202828288078
16170MYMedulla13.304691076278720.1204218864441
16170OLFOlfactory bulb2.799843072891242.77719712257385
16170PPons1.382147789001462.19811105728149
16170PALPallidum0.6868902295827870.784096263349056
16170RHPRetrohippocampal region2.603663086891171.90512883663177
16170sAMYStriatum-like amygdalar nuclei0.9551690667867660.807605683803558
16170STRStriatum0.6139885336160660.553065523505211
16170STRdStriatum dorsal region0.4240312129259110.386637151241302
16170STRvStriatum ventral region1.026620671153070.857456021010876
16170THThalamus3.016125559806824.09488868713379
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3603GO:0005125IEAFunctioncytokine activity
3603GO:0005515IEAFunctionprotein binding
3603GO:0005615TASComponentextracellular space
3603GO:0006935IEAProcesschemotaxis
3603GO:0006955TASProcessimmune response
3603GO:0050896IEAProcessresponse to stimulus
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3759NP_000882.1potassium inwardly-rectifying channel J2HPRD02815
-3766NP_002232.2potassium inwardly-rectifying channel, subfamily J, member 10HPRD03732
-4659NP_002471.1protein phosphatase 1, regulatory (inhibitor) subunit 12AHPRD03606
-3750NP_004970.3potassium voltage-gated channel, Shal-related subfamily, member 1HPRD02233
-54776NP_060077.1protein phosphatase 1, regulatory subunit 12CHPRD11452
-3761NP_690607.1potassium inwardly-rectifying channel J4HPRD02738
-3772NP_733932.1potassium inwardly-rectifying channel J15HPRD03659
AAQ86961.1--Calcium channel alpha 1HPRD04329
AAQ86961.1--Kv4.2HPRD04329
AAQ86961.1--Kv4.3HPRD04329
AAQ86961.1--MBS85HPRD04329
AAQ86961.13750-Potassium voltage gated channel, shal related subfamily member 1HPRD04329
AAQ86961.13751-KCND2HPRD04329
AAQ86961.13759-Potassium channel, inwardly rectifying, subfamily J, member 2HPRD04329
AAQ86961.13761-HIRHPRD04329
AAQ86961.13761-Inward rectifier potassium channel 4HPRD04329
AAQ86961.13766-Glial inwardly rectifying potassium channel Kir4.1HPRD04329
AAQ86961.13772-Inward rectifier potassium channel Kir4.2HPRD04329
AAQ86961.13772-KCNJ15HPRD04329
AAQ86961.14659-Myosin phosphatase target subunit 1HPRD04329
AAQ86961.14660-Myosin phosphatase target subunit 2HPRD04329
AAQ86961.154776-Protein phosphatase 1, regulatory subunit 12CHPRD04329
AAQ86961.13603AAQ86961.1Homo sapiens neural interleukin 16 precursor protein mRNA, complete cds.HPRD04329
AAQ86961.14660NP_002472.1protein phosphatase 1, regulatory (inhibitor) subunit 12B isoform aBIND178905
AAQ86961.14660NP_115288.1protein phosphatase 1, regulatory (inhibitor) subunit 12B isoform bHPRD04794
NP_004504.34659NP_002471.1protein phosphatase 1, regulatory (inhibitor) subunit 12ABIND178902
NP_004504.34660NP_002472.1protein phosphatase 1, regulatory (inhibitor) subunit 12B isoform aBIND178903
NP_004504.354776NP_060077.1protein phosphatase 1, regulatory subunit 12CBIND178904
NP_004504.3155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3603IPR001478PDZPDZ/DHR/GLGF
3603IL16_HUMANQ14005IPR001478PDZPDZ/DHR/GLGF

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