Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3604
Official Symbol:TNFRSF9
Other Aliases:4-1BB|CD137|CDw137|ILA|MGC2172
See related:HGNC:11924|MIM:602250|HPRD:03767
Chromosome:1
Location:1p36
Gene Description:tumor necrosis factor receptor superfamily, member 9
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0227
ORGANISM:human
Entrez Gene ID:3604
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:21942
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
21942CBCerebellum3.671733617782595.7978138923645
21942CTXCerebral cortex5.384858608245854.6012864112854
21942HIPHippocampal region2.799798727035522.53348994255066
21942HPFHippocampal formation1.862922668457031.57386195659637
21942HYHypothalamus0.1398839354515080.115998357534409
21942LSXLateral septal complex0.2368374764919280.293574243783951
21942MBMidbrain1.703350663185122.49964642524719
21942MYMedulla2.901207208633424.59626293182373
21942OLFOlfactory bulb5.873211860656745.07683086395264
21942PPons1.507461309432983.04156947135925
21942PALPallidum0.737522244453430.758509635925293
21942RHPRetrohippocampal region0.448000162839890.351155757904053
21942sAMYStriatum-like amygdalar nuclei0.8565048575401311.34822010993958
21942STRStriatum0.7003225088119510.707245230674744
21942STRdStriatum dorsal region0.4487892091274260.497420638799667
21942STRvStriatum ventral region1.546383857727051.0745542049408
21942THThalamus0.9906540513038640.89610368013382
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3604GO:0004872TASFunctionreceptor activity
3604GO:0005887TASComponentintegral to plasma membrane
3604GO:0006917TASProcessinduction of apoptosis
3604GO:0006955NRProcessimmune response
3604GO:0008285TASProcessnegative regulation of cell proliferation
3604GO:0016020IEAComponentmembrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-8744NP_003802.1tumor necrosis factor (ligand) superfamily, member 9HPRD05861
NP_001552.28744-Tumor necrosis factor ligand superfamily, member 9HPRD03767
NP_001552.27185NP_005649.1TNF receptor-associated factor 1HPRD03767
NP_001552.27185NP_005649.1TNF receptor-associated factor 1HPRD03418
NP_001552.27186NP_066961.2TNF receptor-associated factor 2HPRD03767
NP_001552.27186NP_066961.2TNF receptor-associated factor 2HPRD03538
NP_001552.27187NP_663777.1TNF receptor-associated factor 3 isoform 1HPRD03767
NP_001552.27187NP_663777.1TNF receptor-associated factor 3 isoform 1HPRD03539
NP_001552.2122769NP_689542.2peptidylprolyl isomerase (cyclophilin)-like 5 isoform 1HPRD15164
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3604TNR9_HUMANQ07011IPR0060582Fe2S_fd_BS2Fe-2S ferredoxin, iron-sulfur binding site
3604TNR9_HUMANQ07011IPR013032EGF_like_regEGF-like region
3604TNR9_HUMANQ07011IPR001368TNFR_c6TNFR/CD27/30/40/95 cysteine-rich region

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