Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3655
Official Symbol:ITGA6
Other Aliases:CD49f
See related:HGNC:6142|MIM:147556|HPRD:00945
Chromosome:2
Location:2q31.1
Gene Description:integrin, alpha 6
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0338
ORGANISM:human
Entrez Gene ID:3655
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-0.51
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
16403CBCerebellum15.90450477600117.1542015075684
16403CTXCerebral cortex2.858765125274661.77201879024506
16403HIPHippocampal region4.366625308990483.59633493423462
16403HPFHippocampal formation5.146234035491944.01513338088989
16403HYHypothalamus4.560753822326663.25451064109802
16403LSXLateral septal complex0.7954514026641850.842577993869781
16403MBMidbrain2.576901912689212.41237878799438
16403MYMedulla7.006272792816167.65931558609009
16403OLFOlfactory bulb21.589345932006816.4441719055176
16403PPons4.396560192108154.81036710739136
16403PALPallidum2.967727422714232.37647390365601
16403RHPRetrohippocampal region6.520381450653084.67847442626953
16403sAMYStriatum-like amygdalar nuclei2.316154479980471.67004382610321
16403STRStriatum1.515852570533751.06113862991333
16403STRdStriatum dorsal region0.6210139989852910.386749744415283
16403STRvStriatum ventral region4.623821258544922.93120408058167
16403THThalamus2.724100112915042.00855112075806
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3655GO:0004872IEAFunctionreceptor activity
3655GO:0005509IEAFunctioncalcium ion binding
3655GO:0005515IEAFunctionprotein binding
3655GO:0007044TASProcesscell-substrate junction assembly
3655GO:0007155IEAProcesscell adhesion
3655GO:0007160NRProcesscell-matrix adhesion
3655GO:0007229IEAProcessintegrin-mediated signaling pathway
3655GO:0008305IEAComponentintegrin complex
3655GO:0016020IEAComponentmembrane
3655GO:0016021IEAComponentintegral to membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5829BAA18998.1paxillin gammaHPRD03937
-3691NP_000204.2integrin, beta 4HPRD00946
-10755NP_005707.1regulator of G-protein signalling 19 interacting protein 1 isoform 1HPRD05462
-3688NP_391987.1integrin beta 1 isoform 1C-1 precursorHPRD00628
NP_000201.1--p67 LBPHPRD00945
NP_000201.13691-Integrin beta 4HPRD00945
NP_000201.110755-GIPCHPRD00945
NP_000201.15829-PaxillinHPRD00945
NP_000201.13691NP_000204.2integrin, beta 4BIND24516
NP_000201.13688NP_002202.2integrin beta 1 isoform 1A precursorBIND24515
NP_000201.13732NP_002222.1CD82 antigen isoform 1HPRD00945
NP_000201.13732NP_002222.1CD82 antigen isoform 1HPRD09004
NP_000201.17106NP_003262.1tetraspanin 4 isoform aHPRD00945
NP_000201.17106NP_003262.1tetraspanin 4 isoform aHPRD04033
NP_000201.13688NP_391987.1integrin beta 1 isoform 1C-1 precursorHPRD00945
NP_000201.1155807NP_057852.2Vpr--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3655IPR013517FG-GAPFG-GAP
3655IPR000413Integrin_alphaIntegrins alpha chain
3655IPR013513Integrin_alpha_CIntegrin alpha chain, C-terminal cytoplasmic region
3655IPR013649Integrin_alpha-2Integrin alpha-2
3655IPR013519Int_alpha_beta-pIntegrin alpha beta-propellor

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