Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3688
Official Symbol:ITGB1
Other Aliases:CD29|FNRB|GPIIA|MDF2|MSK12|VLAB
See related:HGNC:6153|MIM:135630|HPRD:00628
Chromosome:10
Location:10p11.2
Gene Description:integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIL0282
ORGANISM:human
Entrez Gene ID:3688
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:7694454
Addiction Drug:ALCOHOL
Addiction Drug Detail:Alcoholic liver disease
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
16412CBCerebellum23.005632400512729.4142570495605
16412CTXCerebral cortex22.300532341003413.9932851791382
16412HIPHippocampal region14.211394309997614.2401905059814
16412HPFHippocampal formation14.721698284149212.6675152778625
16412HYHypothalamus18.369720935821515.1930370330811
16412LSXLateral septal complex14.825736999511712.1998920440674
16412MBMidbrain14.201082229614314.3510842323303
16412MYMedulla23.142512321472226.7783632278442
16412OLFOlfactory bulb29.358735084533719.1306757926941
16412PPons17.975229263305720.4926786422729
16412PALPallidum18.825394630432117.5280542373657
16412RHPRetrohippocampal region14.983592510223410.5442388057709
16412sAMYStriatum-like amygdalar nuclei12.311652660369910.1343765258789
16412STRStriatum12.997961997985810.7372884750366
16412STRdStriatum dorsal region13.131387710571311.3924679756165
16412STRvStriatum ventral region11.57828855514537.93432307243347
16412THThalamus22.733423233032216.3156309127808
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3688GO:0001726TASComponentruffle
3688GO:0004872IEAFunctionreceptor activity
3688GO:0005515IEAFunctionprotein binding
3688GO:0006968TASProcesscellular defense response
3688GO:0007155IEAProcesscell adhesion
3688GO:0007156TASProcesshomophilic cell adhesion
3688GO:0007160IEAProcesscell-matrix adhesion
3688GO:0007229IEAProcessintegrin-mediated signaling pathway
3688GO:0007275IEAProcessdevelopment
3688GO:0008305IEAComponentintegrin complex
3688GO:0008305NASComponentintegrin complex
3688GO:0016020IEAComponentmembrane
3688GO:0016021IEAComponentintegral to membrane
3688GO:0016477TASProcesscell migration
3688GO:0042802IPIFunctionidentical protein binding
3688GO:0046982NASFunctionprotein heterodimerization activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-10618AAC39542.1Homo sapiens trans-golgi network glycoprotein 51 (TGN) mRNA, complete cds.HPRD04343
-5829BAA18998.1paxillin gammaHPRD03937
-4830NP_000260.1non-metastatic cells 1, protein (NM23A) expressed in isoform bHPRD01131
-3693NP_002204.2integrin, beta 5HPRD00949
-7057NP_003237.1thrombospondin 1HPRD01765
-7529NP_003395.1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptideHPRD03184
-8515NP_003628.2integrin, alpha 10 precursorHPRD04952
-9270NP_004754.1integrin cytoplasmic domain-associated protein 1 isoform 1HPRD06194
-284217NP_005550.2laminin, alpha 1 precursorHPRD01033
-5747NP_005598.3PTK2 protein tyrosine kinase 2 isoform bHPRD02859
-10399NP_006089.1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1BIND194825
-10399NP_006089.1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1BIND216583
-26232NP_036300.2F-box only protein 2HPRD06171
-26548NP_036410.1melusinHPRD02271
-9448NP_663719.1mitogen-activated protein kinase kinase kinase kinase 4 isoform 2HPRD05235
-27231NP_733778.1integrin beta 1 binding protein 3 isoform 2HPRD16371
NP_002202.28516AAA93514.1integrin alpha 8 subunitBIND24525
NP_002202.222801NP_036343.3integrin, alpha 11 precursorBIND24517
NP_002202.24651NP_036466.1myosin XBIND144487
NP_002202.2155871NP_057853.1Tat--
NP_002202.2155871NP_057853.1Tat--
NP_002202.2155871NP_057853.1Tat--
NP_002202.2155871NP_057853.1Tat--
NP_002202.2155871NP_057853.1Tat--
NP_391987.1--LGALS8HPRD00628
NP_391987.15829-PaxillinHPRD00628
NP_391987.15747-FAKHPRD00628
NP_391987.19270-Integrin beta 1 binding protein 1HPRD00628
NP_391987.18515-Integrin alpha 10HPRD00628
NP_391987.1284217-Laminin, alpha 1HPRD00628
NP_391987.110618-Trans-golgi network protein 2HPRD00628
NP_391987.17529-14-3-3 BetaHPRD00628
NP_391987.13693-Integrin, beta 5HPRD00628
NP_391987.14830-Nucleoside diphosphate kinase AHPRD00628
NP_391987.19448-MAP4K4HPRD00628
NP_391987.15578-Protein kinase C alphaHPRD00628
NP_391987.126232-F box protein 2HPRD00628
NP_391987.126548-MelusinHPRD00628
NP_391987.17412NP_001069.1vascular cell adhesion molecule 1 isoform a precursorHPRD01888
NP_391987.17412NP_001069.1vascular cell adhesion molecule 1 isoform a precursorHPRD00628
NP_391987.13732NP_002222.1CD82 antigen isoform 1HPRD09004
NP_391987.13732NP_002222.1CD82 antigen isoform 1HPRD00628
NP_391987.14179NP_002380.3CD46 antigen, complement regulatory protein isoform 1 precursorHPRD00406
NP_391987.14179NP_002380.3CD46 antigen, complement regulatory protein isoform 1 precursorHPRD00628
NP_391987.16520NP_002385.2solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2HPRD01148
NP_391987.16520NP_002385.2solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2HPRD00628
NP_391987.17057NP_003237.1thrombospondin 1HPRD00628
NP_391987.17106NP_003262.1tetraspanin 4 isoform aHPRD00628
NP_391987.17106NP_003262.1tetraspanin 4 isoform aHPRD04033
NP_391987.18516NP_003629.1integrin, alpha 8HPRD10361
NP_391987.13959NP_005558.1galectin 3 binding proteinHPRD00628
NP_391987.13959NP_005558.1galectin 3 binding proteinHPRD02796
NP_391987.110399NP_006089.1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1HPRD00628
NP_391987.17094NP_006280.2talin 1HPRD01726
NP_391987.17094NP_006280.2talin 1HPRD00628
NP_391987.122801NP_036343.2integrin, alpha 11HPRD00628
NP_391987.122801NP_036343.2integrin, alpha 11HPRD05310
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3688IPR013111EGF_extracellEGF, extracellular
3688IPR013032EGF_like_regEGF-like region
3688IPR001169Integrin_beta_CIntegrin beta, C-terminal
3688IPR002369Integrin_B_NIntegrin, beta chain N-terminal
3688IPR012896Integrin_B_tailIntegrin beta tail
3688IPR000434PKD_1Polycystic kidney disease type 1 protein
3688ITB1_HUMANP05556IPR013111EGF_extracellEGF, extracellular
3688ITB1_HUMANP05556IPR013032EGF_like_regEGF-like region
3688ITB1_HUMANP05556IPR001169Integrin_beta_CIntegrin beta, C-terminal
3688ITB1_HUMANP05556IPR002369Integrin_B_NIntegrin, beta chain N-terminal
3688ITB1_HUMANP05556IPR012896Integrin_B_tailIntegrin beta tail
3688ITB1_HUMANP05556IPR000434PKD_1Polycystic kidney disease type 1 protein

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