Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3706
Official Symbol:ITPKA
Other Aliases:-
See related:HGNC:6178|MIM:147521|HPRD:00941
Chromosome:15
Location:15q14-q21
Gene Description:inositol 1,4,5-trisphosphate 3-kinase A
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0279
ORGANISM:human
Entrez Gene ID:3706
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Upregulated
Fold Change:0.67
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
228550CBCerebellum20.3357582092285100.0
228550CTXCerebral cortex100.0100.0
228550HIPHippocampal region100.0100.0
228550HPFHippocampal formation100.0100.0
228550HYHypothalamus6.509996607899677.20111288130283
228550LSXLateral septal complex94.9248313903809100.0
228550MBMidbrain5.921170949935918.03368830680847
228550MYMedulla6.6049764156341611.1545670032501
228550OLFOlfactory bulb67.9958686828613100.0
228550PPons2.977761626243594.42196547985077
228550PALPallidum15.361347198486317.0281209945679
228550RHPRetrohippocampal region100.0100.0
228550sAMYStriatum-like amygdalar nuclei46.117234230041559.0178899765015
228550STRStriatum97.466636657714898.0124778747559
228550STRdStriatum dorsal region99.237632751464899.9742431640625
228550STRvStriatum ventral region100.0100.0
228550THThalamus25.689330577850338.7828912734985
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3706GO:0000166IEAFunctionnucleotide binding
3706GO:0005516IEAFunctioncalmodulin binding
3706GO:0005524IEAFunctionATP binding
3706GO:0007165TASProcesssignal transduction
3706GO:0008440TASFunctioninositol trisphosphate 3-kinase activity
3706GO:0016301IEAFunctionkinase activity
3706GO:0016740IEAFunctiontransferase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_002211.1--CalmodulinHPRD00941
NP_002211.1--CaMK II betaHPRD00941
NP_002211.1--F-actinHPRD00941
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3706IP3KA_HUMANP23677IPR005522IPKInositol polyphosphate kinase

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