Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3725
Official Symbol:JUN
Other Aliases:AP1
See related:HGNC:6204|MIM:165160|HPRD:01302
Chromosome:1
Location:1p32-p31
Gene Description:v-jun sarcoma virus 17 oncogene homolog (avian)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0295
ORGANISM:human
Entrez Gene ID:3725
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:16476
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0529
ORGANISM:human
Entrez Gene ID:3725
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:24516
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:QTL0083
ORGANISM:human
Entrez Gene ID:3725
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
16476CBCerebellum100.0100.0
16476CTXCerebral cortex100.0100.0
16476HIPHippocampal region100.0100.0
16476HPFHippocampal formation100.0100.0
16476HYHypothalamus100.0100.0
16476LSXLateral septal complex100.0100.0
16476MBMidbrain100.0100.0
16476MYMedulla100.0100.0
16476OLFOlfactory bulb100.0100.0
16476PPons100.0100.0
16476PALPallidum100.0100.0
16476RHPRetrohippocampal region100.0100.0
16476sAMYStriatum-like amygdalar nuclei100.0100.0
16476STRStriatum100.0100.0
16476STRdStriatum dorsal region100.0100.0
16476STRvStriatum ventral region100.0100.0
16476THThalamus100.0100.0
KARG Evidence 4
KARG ID:QTL0083
Trait:Chronic ethanol withdrawal
Peak:44.6
Peak Marker:D4Mit186
Parents:B6D2F2 (C57BL/6J x DBA/2J)
Evidence ID:11919667
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3725GO:0000228TASComponentnuclear chromosome
3725GO:0003700TASFunctiontranscription factor activity
3725GO:0003702TASFunctionRNA polymerase II transcription factor activity
3725GO:0006350IEAProcesstranscription
3725GO:0006355IEAProcessregulation of transcription, DNA-dependent
3725GO:0008134IPIFunctiontranscription factor binding
3725GO:0043565IEAFunctionsequence-specific DNA binding
3725GO:0046983IEAFunctionprotein dimerization activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5925NP_000312.1retinoblastoma 1HPRD01574
-7421NP_000367.1vitamin D (1,25-dihydroxyvitamin D3) receptorHPRD03463
-6142NP_000971.1ribosomal protein L18aHPRD16045
-7153NP_001058.2DNA topoisomerase II, alpha isozymeHPRD00536
-4654NP_002469.2myogenic differentiation 1HPRD01166
-5595NP_002737.1mitogen-activated protein kinase 3HPRD03479
-6497NP_003027.1v-ski sarcoma viral oncogene homologHPRD01271
-6602NP_003067.2SWI/SNF-related matrix-associated actin-dependent regulator of chromatin d1 isoform aHPRD03438
-6688NP_003111.1spleen focus forming virus (SFFV) proviral integration oncogene spi1HPRD01305
-6775NP_003142.1signal transducer and activator of transcription 4HPRD02779
-6908NP_003185.1TATA box binding proteinHPRD02511
-4779NP_003195.1nuclear factor (erythroid-derived 2)-like 1HPRD01223
-7050NP_003235.1TG-interacting factor isoform cHPRD04023
-7169NP_003280.2tropomyosin 2 (beta) isoform 1HPRD11768
-8204NP_003480.1receptor interacting protein 140HPRD03927
-8648NP_003734.3nuclear receptor coactivator 1 isoform 1HPRD04070
-9188NP_004719.2DEAD (Asp-Glu-Ala-Asp) box polypeptide 21HPRD05895
-4089NP_005350.1MAD, mothers against decapentaplegic homolog 4HPRD02995
-4094NP_005351.2v-maf musculoaponeurotic fibrosarcoma oncogene homolog isoform aHPRD01518
-8061NP_005429.1FOS-like antigen 1HPRD00643
-4666NP_005585.1nascent-polypeptide-associated complex alpha polypeptideHPRD03137
-6942NP_005641.1transcription factor 20 isoform 1HPRD04378
-4087NP_005892.1Sma- and Mad-related protein 2HPRD03221
-4088NP_005893.1MAD, mothers against decapentaplegic homolog 3HPRD04380
-4670NP_005959.2heterogeneous nuclear ribonucleoprotein M isoform aHPRD01188
-10987NP_006828.2COP9 signalosome subunit 5HPRD06888
-6772NP_009330.1signal transducer and activator of transcription 1 isoform alphaHPRD02777
-5891NP_055041.1MAPK/MAK/MRK overlapping kinaseHPRD09310
-10514NP_055335.1MYB binding protein 1aHPRD05349
-9325NP_057297.2thyroid hormone receptor interactor 4HPRD05140
-5970NP_068810.1v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65HPRD01241
-64326NP_071902.2ring finger and WD repeat domain 2 isoform aHPRD07455
-5371NP_150241.1promyelocytic leukemia protein isoform 1HPRD00023
-122953NP_569736.1Jun dimerization proteinHPRD16360
-6667NP_612482.2Sp1 transcription factorHPRD01796
-5599NP_620637.1mitogen-activated protein kinase 8 isoform 1HPRD03100
-6774NP_644805.1signal transducer and activator of transcription 3 isoform 1HPRD00026
-9584NP_909125.1RNA-binding region containing protein 2 isoform cHPRD09201
-6689Q01892Transcription factor Spi-B.HPRD06007
NM_002228.38570NP_003676.1KH-type splicing regulatory protein (FUSE binding protein 2)BIND144434
NP_002219.1--VP16HPRD01302
NP_002219.1--p52/54HPRD01302
NP_002219.1--L18aHPRD01302
NP_002219.1--IE2 86HPRD01302
NP_002219.1--E1A 52RHPRD01302
NP_002219.1--TFIIBHPRD01302
NP_002219.1--E-7HPRD01302
NP_002219.1--T antigenHPRD01302
NP_002219.1--MEQHPRD01302
NP_002219.1--Nuclear receptor activator 2HPRD01302
NP_002219.1--En-1HPRD01302
NP_002219.1--HexHPRD01302
NP_002219.1--CAPERHPRD01302
NP_002219.1--NDHIIHPRD01302
NP_002219.1--Ubc9HPRD01302
NP_002219.1--NFYHPRD01302
NP_002219.14654-Myogenic differentiation antigen 1HPRD01302
NP_002219.15595-ERK1HPRD01302
NP_002219.16908-TATA box binding proteinHPRD01302
NP_002219.14094-c-MafHPRD01302
NP_002219.15599-JNK1HPRD01302
NP_002219.110514-P160HPRD01302
NP_002219.17153-DNA topoisomerase II alphaHPRD01302
NP_002219.15449-PIT 1HPRD01302
NP_002219.16942-Transcription factor 20HPRD01302
NP_002219.110987-COP9, subunit 5HPRD01302
NP_002219.15599--BIND195759
NP_002219.15601--BIND194865
NP_002219.15599--BIND196683
NP_002219.15970-NFKB3HPRD01302
NP_002219.14666-Nascent polypeptide associated complex, alpha polypeptideHPRD01302
NP_002219.18648-SRC1HPRD01302
NP_002219.15371-PMLHPRD01302
NP_002219.14088-SMAD3HPRD01302
NP_002219.14779-Nuclear factor erythroid 2 like 1HPRD01302
NP_002219.15925-Retinoblastoma 1HPRD01302
NP_002219.16689-SPIB transcription factorHPRD01302
NP_002219.14087-SMAD2HPRD01302
NP_002219.14089-SMAD4HPRD01302
NP_002219.17421-Vitamin D receptorHPRD01302
NP_002219.15891-Renal tumor antigen 1HPRD01302
NP_002219.16772-STAT1HPRD01302
NP_002219.16774-STAT3HPRD01302
NP_002219.16667-Transcription factor Sp1HPRD01302
NP_002219.16602-SMARCD1HPRD01302
NP_002219.17050-TGIFHPRD01302
NP_002219.19584-Splicing factor HCC1HPRD01302
NP_002219.18061-Fos-like antigen 1HPRD01302
NP_002219.16775-STAT4HPRD01302
NP_002219.14670-Heterogeneous nuclear ribonucleoprotein MHPRD01302
NP_002219.19188-DDX21HPRD01302
NP_002219.16497-C SkiHPRD01302
NP_002219.19325-Thyroid hormone receptor interactor 4HPRD01302
NP_002219.16688-SPI1HPRD01302
NP_002219.18204-Nuclear receptor interacting protein 1HPRD01302
NP_002219.164326-COP1HPRD01302
NP_002219.18061NC_000011.8Homo sapiens chromosome 11, reference assemblyBIND300873
NP_002219.15925NP_000312.1retinoblastoma 1BIND182754
NP_002219.155294NP_001013433.1F-box protein FBW7 isoform 3BIND315965
NP_002219.13725NP_002219.1v-jun avian sarcoma virus 17 oncogene homologHPRD01302
NP_002219.13725NP_002219.1v-jun avian sarcoma virus 17 oncogene homologBIND153135
NP_002219.13725NP_002219.1v-jun avian sarcoma virus 17 oncogene homologBIND145575
NP_002219.13725NP_002219.1v-jun avian sarcoma virus 17 oncogene homologBIND215340
NP_002219.13726NP_002220.1jun B proto-oncogeneBIND151563
NP_002219.15587NP_002733.1protein kinase D1HPRD05668
NP_002219.15587NP_002733.1protein kinase D1HPRD01302
NP_002219.15599NP_002741.1mitogen-activated protein kinase 8 isoform 2BIND134102
NP_002219.15600NP_002742.3mitogen-activated protein kinase 11BIND196723
NP_002219.15601NP_002743.3mitogen-activated protein kinase 9 isoform 1BIND134104
NP_002219.15602NP_002744.1mitogen-activated protein kinase 10 isoform 1BIND134096
NP_002219.17329NP_003336.1ubiquitin-conjugating enzyme E2IHPRD09045
NP_002219.17533NP_003396.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, eta polypeptideBIND199702
NP_002219.18841NP_003874.2histone deacetylase 3HPRD01302
NP_002219.16872NP_004597.2TBP-associated factor 1 isoform 1HPRD01302
NP_002219.16872NP_004597.2TBP-associated factor 1 isoform 1HPRD02436
NP_002219.15300NP_006212.1protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1HPRD01302
NP_002219.15300NP_006212.1protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1HPRD03031
NP_002219.110538NP_006390.1basic leucine zipper transcription factor, ATF-likeHPRD09820
NP_002219.110538NP_006390.1basic leucine zipper transcription factor, ATF-likeHPRD01302
NP_002219.125920NP_056271.2cofactor of BRCA1HPRD10845
NP_002219.18554NP_057250.1protein inhibitor of activated STAT, 1HPRD16029
NP_002219.151177NP_057358.2OC120BIND215337
NP_002219.154861NP_060189.2SNF related kinaseHPRD18082
NP_002219.155690NP_060496.2phosphofurin acidic cluster sorting protein 1HPRD06320
NP_002219.155690NP_060496.2phosphofurin acidic cluster sorting protein 1HPRD01302
NP_002219.155294NP_060785.2F-box protein FBW7 isoform 2BIND315963
NP_002219.15970NP_068810.2v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65BIND145578
NP_002219.164326NP_071902.2ring finger and WD repeat domain 2 isoform aBIND57830
NP_002219.155294NP_361014.1F-box protein FBW7 isoform 1BIND315964
NP_002219.15602NP_620448.1mitogen-activated protein kinase 10 isoform 2BIND134099
NP_002219.15602NP_620448.1mitogen-activated protein kinase 10 isoform 2BIND297409
NP_002219.15599NP_620634.1mitogen-activated protein kinase 8 isoform 3BIND134103
NP_002219.15599NP_620635.1mitogen-activated protein kinase 8 isoform 4BIND134105
NP_002219.15599NP_620637.1mitogen-activated protein kinase 8 isoform 1BIND134101
NP_002219.15599NP_620637.1mitogen-activated protein kinase 8 isoform 1BIND297408
NP_002219.15601NP_620707.1mitogen-activated protein kinase 9 isoform 2BIND134100
NP_002219.15601NP_620708.1mitogen-activated protein kinase 9 isoform 3BIND134098
NP_002219.15601NP_620709.1mitogen-activated protein kinase 9 isoform 4BIND134097
NP_002219.18550NP_620777.1mitogen-activated protein kinase-activated protein kinase 5 isoform 2HPRD09467
NP_002219.18550NP_620777.1mitogen-activated protein kinase-activated protein kinase 5 isoform 2HPRD01302
NP_002219.19586NP_878901.1cAMP responsive element binding protein 5HPRD01302
NP_002219.19586NP_878901.1cAMP responsive element binding protein 5HPRD09896
NP_002219.1155871NP_057853.1Tat--
NP_002219.1155871NP_057853.1Tat--
NP_002219.1155871NP_057853.1Tat--
NP_002219.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3725JUN_HUMANP05412IPR011616bZIP_1bZIP transcription factor, bZIP_1
3725JUN_HUMANP05412IPR011700bZIP_2Basic leucine zipper
3725JUN_HUMANP05412IPR005643JNKJun-like transcription factor
3725JUN_HUMANP05412IPR001630Leuzip_CREBcAMP response element binding (CREB) protein
3725JUN_HUMANP05412IPR002112Leuzip_JunTranscription factor Jun
3725JUN_HUMANP05412IPR004827TF_bZIPBasic-leucine zipper (bZIP) transcription factor

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