Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3736
Official Symbol:KCNA1
Other Aliases:AEMK|EA1|HUK1|KV1.1|MBK1|MGC126782|MGC138385|MK1|RBK1
See related:HGNC:6218|MIM:176260|HPRD:08885
Chromosome:12
Location:12p13
Gene Description:potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0612
ORGANISM:human
Entrez Gene ID:3736
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:24520
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
16485CBCerebellum94.0967445373535100.0
16485CTXCerebral cortex100.0100.0
16485HIPHippocampal region90.4227523803711100.0
16485HPFHippocampal formation85.2749862670898100.0
16485HYHypothalamus32.297840118408231.4990510940552
16485LSXLateral septal complex58.060253143310550.7313346862793
16485MBMidbrain69.600749969482490.9235076904297
16485MYMedulla79.5910835266113100.0
16485OLFOlfactory bulb77.123081207275481.6889991760254
16485PPons70.1021900177002100.0
16485PALPallidum55.014297485351660.3220348358154
16485RHPRetrohippocampal region79.918563842773482.618537902832
16485sAMYStriatum-like amygdalar nuclei29.745690345764225.9528064727783
16485STRStriatum94.563838958740288.0408897399902
16485STRdStriatum dorsal region96.979038238525489.2914772033691
16485STRvStriatum ventral region100.0100.0
16485THThalamus74.547565460205193.7452812194824
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3736GO:0005251TASFunctiondelayed rectifier potassium channel activity
3736GO:0005515IEAFunctionprotein binding
3736GO:0005624NRComponentmembrane fraction
3736GO:0006812IEAProcesscation transport
3736GO:0006813TASProcesspotassium ion transport
3736GO:0006936NRProcessmuscle contraction
3736GO:0007268TASProcesssynaptic transmission
3736GO:0008076TASComponentvoltage-gated potassium channel complex
3736GO:0015079TASFunctionpotassium ion transporter activity
3736GO:0016020IEAComponentmembrane
3736GO:0016021IEAComponentintegral to membrane
3736GO:0030955IEAFunctionpotassium ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-23704NP_542402.1potassium voltage-gated channel, Isk-related family, member 4HPRD09689
NP_000208.123704-Potassium channel voltage gated ISK related subfamily member 4HPRD08885
NP_000208.18514NP_003627.1potassium voltage-gated channel, shaker-related subfamily, beta member 2 isoform 1HPRD08885
NP_000208.18514NP_003627.1potassium voltage-gated channel, shaker-related subfamily, beta member 2 isoform 1HPRD03090
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3736KCNA1_HUMANQ09470IPR005821Ion_transIon transport
3736KCNA1_HUMANQ09470IPR013099Ion_trans_2_bacIon transport 2, bacterial
3736KCNA1_HUMANQ09470IPR013621Ion_trans_NIon transport N-terminal
3736KCNA1_HUMANQ09470IPR001622K+channel_poreK+ channel, pore region
3736KCNA1_HUMANQ09470IPR004048KV11channelKv1.1 voltage-gated K+ channel
3736KCNA1_HUMANQ09470IPR004049KV12channelKv1.2 voltage-gated K+ channel
3736KCNA1_HUMANQ09470IPR004050KV13channelKv1.3 voltage-gated K+ channel
3736KCNA1_HUMANQ09470IPR003971Kv9_channelKv9 voltage-gated K+ channel
3736KCNA1_HUMANQ09470IPR003968Kv_channelKv channel
3736KCNA1_HUMANQ09470IPR003091K_channelVoltage-dependent potassium channel
3736KCNA1_HUMANQ09470IPR003131K_tetraK+ channel tetramerisation
3736KCNA1_HUMANQ09470IPR005820M+channel_nlgCation channel, non-ligand gated
3736KCNA1_HUMANQ09470IPR003973Shab_channelShab voltage-gated K+ channel
3736KCNA1_HUMANQ09470IPR003972Shaker_channelShaker voltage-gated K+ channel

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