Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3742
Official Symbol:KCNA6
Other Aliases:HBK2|KV1.6
See related:HGNC:6225|MIM:176257|HPRD:08884
Chromosome:12
Location:12p13
Gene Description:potassium voltage-gated channel, shaker-related subfamily, member 6
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0478
ORGANISM:human
Entrez Gene ID:3742
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:64358
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
16494CBCerebellum30.820295333862373.3564529418945
16494CTXCerebral cortex76.089708328247171.6594638824463
16494HIPHippocampal region23.460010528564529.8034763336182
16494HPFHippocampal formation33.859979629516638.46510887146
16494HYHypothalamus37.188014984130936.3646640777588
16494LSXLateral septal complex15.079977035522512.5000818967819
16494MBMidbrain26.144729614257826.3743839263916
16494MYMedulla40.652069091796950.2202739715576
16494OLFOlfactory bulb66.227703094482469.7014217376709
16494PPons33.663656234741240.0687789916992
16494PALPallidum39.050067901611342.7968082427979
16494RHPRetrohippocampal region49.359390258789148.9020290374756
16494sAMYStriatum-like amygdalar nuclei49.807907104492251.4942665100098
16494STRStriatum32.508944511413630.4394397735596
16494STRdStriatum dorsal region30.243051528930727.5440702438354
16494STRvStriatum ventral region38.548952102661135.9114284515381
16494THThalamus54.636327743530355.922737121582
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3742GO:0005249TASFunctionvoltage-gated potassium channel activity
3742GO:0005515IEAFunctionprotein binding
3742GO:0005624NRComponentmembrane fraction
3742GO:0006812IEAProcesscation transport
3742GO:0006813TASProcesspotassium ion transport
3742GO:0008076TASComponentvoltage-gated potassium channel complex
3742GO:0016020IEAComponentmembrane
3742GO:0016021IEAComponentintegral to membrane
3742GO:0030955IEAFunctionpotassium ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3742KCNA6_HUMANP17658IPR000101GGT_peptidaseGamma-glutamyltranspeptidase
3742KCNA6_HUMANP17658IPR005821Ion_transIon transport
3742KCNA6_HUMANP17658IPR013099Ion_trans_2_bacIon transport 2, bacterial
3742KCNA6_HUMANP17658IPR013621Ion_trans_NIon transport N-terminal
3742KCNA6_HUMANP17658IPR001622K+channel_poreK+ channel, pore region
3742KCNA6_HUMANP17658IPR004050KV13channelKv1.3 voltage-gated K+ channel
3742KCNA6_HUMANP17658IPR004052KV15channelKv1.5 voltage-gated K+ channel
3742KCNA6_HUMANP17658IPR004053KV16channelKv1.6 voltage-gated K+ channel
3742KCNA6_HUMANP17658IPR003971Kv9_channelKv9 voltage-gated K+ channel
3742KCNA6_HUMANP17658IPR003968Kv_channelKv channel
3742KCNA6_HUMANP17658IPR003091K_channelVoltage-dependent potassium channel
3742KCNA6_HUMANP17658IPR003131K_tetraK+ channel tetramerisation
3742KCNA6_HUMANP17658IPR005820M+channel_nlgCation channel, non-ligand gated
3742KCNA6_HUMANP17658IPR003973Shab_channelShab voltage-gated K+ channel
3742KCNA6_HUMANP17658IPR003972Shaker_channelShaker voltage-gated K+ channel

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