Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3745
Official Symbol:KCNB1
Other Aliases:DRK1|KV2.1|h-DRK1
See related:HGNC:6231|MIM:600397|HPRD:08983
Chromosome:20
Location:20q13.2
Gene Description:potassium voltage-gated channel, Shab-related subfamily, member 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0296
ORGANISM:human
Entrez Gene ID:3745
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:16500
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3745GO:0005251NRFunctiondelayed rectifier potassium channel activity
3745GO:0005515IPIFunctionprotein binding
3745GO:0005624NRComponentmembrane fraction
3745GO:0006812IEAProcesscation transport
3745GO:0006813IEAProcesspotassium ion transport
3745GO:0008076IEAComponentvoltage-gated potassium channel complex
3745GO:0016020IEAComponentmembrane
3745GO:0030955IEAFunctionpotassium ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3755NP_002228.2potassium voltage-gated channel, subfamily G, member 1 isoform 1HPRD04809
-6804NP_004594.1syntaxin 1A (brain)HPRD01721
-5791NP_006495.1protein tyrosine phosphatase, receptor type, E isoform 1 precursorHPRD02956
NP_004966.1--KCNG3HPRD08983
NP_004966.1--KCNG4HPRD08983
NP_004966.1--KCNV2HPRD08983
NP_004966.13755-KH2HPRD08983
NP_004966.15791-Protein tyrosine phosphatase, receptor type, EHPRD08983
NP_004966.16804-Syntaxin 1AHPRD08983
NP_004966.16616NP_003072.2synaptosomal-associated protein 25 isoform SNAP25AHPRD08983
NP_004966.16616NP_003072.2synaptosomal-associated protein 25 isoform SNAP25AHPRD02637
NP_004966.13745NP_004966.1potassium voltage-gated channel, Shab-related subfamily, member 1HPRD08983
NP_004966.126251NP_036415.1potassium voltage-gated channel, subfamily G, member 2HPRD12036
NP_004966.1170850NP_579875.1potassium voltage-gated channel, subfamily G, member 3 isoform 1HPRD16232
NP_004966.1169522NP_598004.1potassium channel, subfamily V, member 2HPRD12126
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3745KCNB1_HUMANQ14721IPR005821Ion_transIon transport
3745KCNB1_HUMANQ14721IPR013099Ion_trans_2_bacIon transport 2, bacterial
3745KCNB1_HUMANQ14721IPR013621Ion_trans_NIon transport N-terminal
3745KCNB1_HUMANQ14721IPR001622K+channel_poreK+ channel, pore region
3745KCNB1_HUMANQ14721IPR004350Kv21channelKv2.1 voltage-gated K+ channel
3745KCNB1_HUMANQ14721IPR003969Kv6_channelKv6 voltage-gated K+ channel
3745KCNB1_HUMANQ14721IPR003970Kv8_channelKv8 voltage-gated K+ channel
3745KCNB1_HUMANQ14721IPR003971Kv9_channelKv9 voltage-gated K+ channel
3745KCNB1_HUMANQ14721IPR003968Kv_channelKv channel
3745KCNB1_HUMANQ14721IPR003091K_channelVoltage-dependent potassium channel
3745KCNB1_HUMANQ14721IPR003131K_tetraK+ channel tetramerisation
3745KCNB1_HUMANQ14721IPR005820M+channel_nlgCation channel, non-ligand gated
3745KCNB1_HUMANQ14721IPR003973Shab_channelShab voltage-gated K+ channel
3745KCNB1_HUMANQ14721IPR003974Shaw_channelShaw voltage-gated K+ channel

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