Knowledgebase for Addiction-Related Genes
KARG (Knowledgebase for Addiction Related
>> Gene Entry
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.
Basic Information Gene ID: 3745 Official Symbol: KCNB1 Other Aliases: DRK1|KV2.1|h-DRK1 See related: HGNC:6231|MIM:600397|HPRD:08983 Chromosome: 20 Location: 20q13.2 Gene Description: potassium voltage-gated channel, Shab-related subfamily, member 1 Gene type: protein-coding Gene Structure: Genomic Context:
KARG Evidence 1 KARG ID: EVIC0296 ORGANISM: human Entrez Gene ID: 3745 Evidence Type: Mapping from mouse Evidence ID Type: Entrez Gene Evidence ID: 16500 Addiction Drug: Addiction Drug Detail: Addiction Brain Area: Drug Effects: Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas) Mouse Entrez Gene ID Brain Region Brain Region Detail Expression Level Expression Density
Gene Ontology Gene ID GO ID Evidence GO Type GO Description 3745 GO:0005251 NR Function delayed rectifier potassium channel activity 3745 GO:0005515 IPI Function protein binding 3745 GO:0005624 NR Component membrane fraction 3745 GO:0006812 IEA Process cation transport 3745 GO:0006813 IEA Process potassium ion transport 3745 GO:0008076 IEA Component voltage-gated potassium channel complex 3745 GO:0016020 IEA Component membrane 3745 GO:0030955 IEA Function potassium ion binding
Interaction Information Gene Product ID Interactant Gene ID Interactant Gene Product ID Interactant Gene Product Name Source Source ID - 3755 NP_002228.2 potassium voltage-gated channel, subfamily G, member 1 isoform 1 HPRD 04809 - 6804 NP_004594.1 syntaxin 1A (brain) HPRD 01721 - 5791 NP_006495.1 protein tyrosine phosphatase, receptor type, E isoform 1 precursor HPRD 02956 NP_004966.1 - - KCNG3 HPRD 08983 NP_004966.1 - - KCNG4 HPRD 08983 NP_004966.1 - - KCNV2 HPRD 08983 NP_004966.1 3755 - KH2 HPRD 08983 NP_004966.1 5791 - Protein tyrosine phosphatase, receptor type, E HPRD 08983 NP_004966.1 6804 - Syntaxin 1A HPRD 08983 NP_004966.1 6616 NP_003072.2 synaptosomal-associated protein 25 isoform SNAP25A HPRD 08983 NP_004966.1 6616 NP_003072.2 synaptosomal-associated protein 25 isoform SNAP25A HPRD 02637 NP_004966.1 3745 NP_004966.1 potassium voltage-gated channel, Shab-related subfamily, member 1 HPRD 08983 NP_004966.1 26251 NP_036415.1 potassium voltage-gated channel, subfamily G, member 2 HPRD 12036 NP_004966.1 170850 NP_579875.1 potassium voltage-gated channel, subfamily G, member 3 isoform 1 HPRD 16232 NP_004966.1 169522 NP_598004.1 potassium channel, subfamily V, member 2 HPRD 12126
Domain Information Gene ID Uniprot/Swissprot ID Uniprot/Swissprot ACC Interpro ID Interpro Short Description Interpro Long Description 3745 KCNB1_HUMAN Q14721 IPR005821 Ion_trans Ion transport 3745 KCNB1_HUMAN Q14721 IPR013099 Ion_trans_2_bac Ion transport 2, bacterial 3745 KCNB1_HUMAN Q14721 IPR013621 Ion_trans_N Ion transport N-terminal 3745 KCNB1_HUMAN Q14721 IPR001622 K+channel_pore K+ channel, pore region 3745 KCNB1_HUMAN Q14721 IPR004350 Kv21channel Kv2.1 voltage-gated K+ channel 3745 KCNB1_HUMAN Q14721 IPR003969 Kv6_channel Kv6 voltage-gated K+ channel 3745 KCNB1_HUMAN Q14721 IPR003970 Kv8_channel Kv8 voltage-gated K+ channel 3745 KCNB1_HUMAN Q14721 IPR003971 Kv9_channel Kv9 voltage-gated K+ channel 3745 KCNB1_HUMAN Q14721 IPR003968 Kv_channel Kv channel 3745 KCNB1_HUMAN Q14721 IPR003091 K_channel Voltage-dependent potassium channel 3745 KCNB1_HUMAN Q14721 IPR003131 K_tetra K+ channel tetramerisation 3745 KCNB1_HUMAN Q14721 IPR005820 M+channel_nlg Cation channel, non-ligand gated 3745 KCNB1_HUMAN Q14721 IPR003973 Shab_channel Shab voltage-gated K+ channel 3745 KCNB1_HUMAN Q14721 IPR003974 Shaw_channel Shaw voltage-gated K+ channel
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