Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:375
Official Symbol:ARF1
Other Aliases:-
See related:HGNC:652|MIM:103180|HPRD:00054
Chromosome:1
Location:1q42
Gene Description:ADP-ribosylation factor 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0182
ORGANISM:human
Entrez Gene ID:375
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15312160
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11840CBCerebellum58.538001060485861.7396783828735
11840CTXCerebral cortex95.324363708496184.3429641723633
11840HIPHippocampal region70.2680664062572.780216217041
11840HPFHippocampal formation74.855573654174874.8382663726807
11840HYHypothalamus58.564824104309156.4273624420166
11840LSXLateral septal complex59.086379051208555.9441475868225
11840MBMidbrain60.587255477905360.6599912643433
11840MYMedulla58.059173583984461.7544279098511
11840OLFOlfactory bulb93.015727996826284.0776786804199
11840PPons57.047891139984159.4546957015991
11840PALPallidum62.67176342010559.7604112625122
11840RHPRetrohippocampal region81.831914901733477.0696678161621
11840sAMYStriatum-like amygdalar nuclei74.9753627777167.5990123748779
11840STRStriatum70.144870758056663.7161922454834
11840STRdStriatum dorsal region69.39731025695862.9996881484985
11840STRvStriatum ventral region69.880743026733463.9948778152466
11840THThalamus70.778371810913166.9605121612549
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
375GO:0000166IEAFunctionnucleotide binding
375GO:0003924TASFunctionGTPase activity
375GO:0005057TASFunctionreceptor signaling protein activity
375GO:0005515IPIFunctionprotein binding
375GO:0005525IEAFunctionGTP binding
375GO:0005622IEAComponentintracellular
375GO:0005795IEAComponentGolgi stack
375GO:0005886TASComponentplasma membrane
375GO:0006364IEAProcessrRNA processing
375GO:0006888IEAProcessER to Golgi vesicle-mediated transport
375GO:0007264IEAProcesssmall GTPase mediated signal transduction
375GO:0015031IEAProcessprotein transport
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5337NP_002653.1phospholipase D1, phophatidylcholine-specificHPRD03855
-8853NP_003878.1development- and differentiation-enhancing factor 2HPRD04820
-8943NP_003929.3adaptor-related protein complex 3, delta 1 subunitHPRD06260
-10945NP_006792.1KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1HPRD00569
-10959NP_006806.1coated vesicle membrane proteinHPRD17984
-11316NP_009194.2epsilon subunit of coatomer protein complex isoform aHPRD06089
-1315NP_057535.1coatomer protein complex, subunit betaHPRD02981
-9266NP_059431.1pleckstrin homology, Sec7 and coiled/coil domains 2 isoform 1HPRD03925
-23163NP_619525.1ADP-ribosylation factor binding protein 3 isoform longHPRD10443
NM_001658.26780NP_059346.1staufen isoform aBIND209293
NP_001019398.1---BIND315291
NP_001649.1--Cytohesin 1HPRD00054
NP_001649.1--Gamma-CopHPRD00054
NP_001649.1--GGA3HPRD00054
NP_001649.1--p23HPRD00054
NP_001649.1--Beta3-adaptinHPRD00054
NP_001649.1--GGA1HPRD00054
NP_001649.1--M3 muscarinic receptorHPRD00054
NP_001649.1---BIND54464
NP_001649.19266-Cytohesin 2HPRD00054
NP_001649.15337-PLD1HPRD00054
NP_001649.18853-PYK C terminus associated proteinHPRD00054
NP_001649.11315-Coatomer protein complex, subunit betaHPRD00054
NP_001649.111316-Coatomer protein complex, subunit epsilonHPRD00054
NP_001649.110945-Endoplasmic reticulum KDEL receptorHPRD00054
NP_001649.18943-Adaptin, deltaHPRD00054
NP_001649.18394AAC50911.1Human 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha mRNA, clone PIP5KIa2, and translated productsHPRD04470
NP_001649.18394AAC50911.1Human 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha mRNA, clone PIP5KIa2, and translated productsHPRD00054
NP_001649.184725AAK55424.1Homo sapiens phosphoinositol 4-phosphate adaptor protein-2 (FAPP2) mRNA, complete cds.HPRD10555
NP_001649.1375NP_001649.1ADP-ribosylation factor 1HPRD00054
NP_001649.14194NP_002384.1mouse double minute 4 homologHPRD00054
NP_001649.14194NP_002384.1mouse double minute 4 homologHPRD04082
NP_001649.14869NP_002511.1nucleophosmin 1 isoform 1HPRD01246
NP_001649.15338NP_002654.2phospholipase D2HPRD03857
NP_001649.15338NP_002654.2phospholipase D2HPRD00054
NP_001649.19179NP_004713.2adaptor-related protein complex 4, mu 1 subunitHPRD03803
NP_001649.19179NP_004713.2adaptor-related protein complex 4, mu 1 subunitHPRD00054
NP_001649.19267NP_004753.1pleckstrin homology, Sec7 and coiled/coil domains 1 isoform 1HPRD01630
NP_001649.19267NP_004753.1pleckstrin homology, Sec7 and coiled/coil domains 1 isoform 1HPRD00054
NP_001649.15898NP_005393.2ras related v-ral simian leukemia viral oncogene homolog AHPRD01549
NP_001649.15898NP_005393.2ras related v-ral simian leukemia viral oncogene homolog AHPRD00054
NP_001649.110972NP_006818.2transmembrane trafficking proteinHPRD12013
NP_001649.123647NP_036534.1ADP-ribosylation factor interacting protein 2 (arfaptin 2)HPRD07209
NP_001649.123647NP_036534.1ADP-ribosylation factor interacting protein 2 (arfaptin 2)HPRD00054
NP_001649.126088NP_037497.1golgi associated, gamma adaptin ear containing, ARF binding protein 1 isoform 1HPRD12078
NP_001649.126088NP_037497.1golgi associated, gamma adaptin ear containing, ARF binding protein 1 isoform 1HPRD12078
NP_001649.127236NP_055262.1ADP-ribosylation factor interacting protein 1 isoform 2HPRD09331
NP_001649.127236NP_055262.1ADP-ribosylation factor interacting protein 1 isoform 2HPRD00054
NP_001649.123062NP_055859.1ADP-ribosylation factor binding protein 2HPRD09347
NP_001649.155738NP_060679.1ADP-ribosylation factor GTPase activating protein 1 isoform aHPRD06443
NP_001649.155738NP_060679.1ADP-ribosylation factor GTPase activating protein 1 isoform aHPRD00054
NP_001649.123163NP_619525.1ADP-ribosylation factor binding protein 3 isoform longHPRD00054
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
375ARF1_HUMANP84077IPR006688ARFADP-ribosylation factor
375ARF1_HUMANP84077IPR006689ARF/SARARF/SAR superfamily
375ARF1_HUMANP84077IPR013753RasRas
375ARF1_HUMANP84077IPR001806Ras_trnsfrmngRas GTPase

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