Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3751
Official Symbol:KCND2
Other Aliases:KIAA1044|KV4.2|MGC119702|MGC119703|RK5
See related:HGNC:6238|MIM:605410|HPRD:09254
Chromosome:7
Location:7q31
Gene Description:potassium voltage-gated channel, Shal-related subfamily, member 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0249
ORGANISM:human
Entrez Gene ID:3751
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:16508
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0466
ORGANISM:human
Entrez Gene ID:3751
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:65180
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
16508CBCerebellum35.0372872352644.6754422187805
16508CTXCerebral cortex12.32878690958029.70388346910477
16508HIPHippocampal region25.349124431610143.5759916305542
16508HPFHippocampal formation19.3995029926327.4712381362915
16508HYHypothalamus1.490370161831381.45605862140656
16508LSXLateral septal complex1.720829933881761.74027165770531
16508MBMidbrain6.246964424848566.71444138884544
16508MYMedulla8.6143252849578910.2284473180771
16508OLFOlfactory bulb24.633358955383325.9408361911774
16508PPons7.252530574798588.48305529356003
16508PALPallidum2.718512237071992.52556222677231
16508RHPRetrohippocampal region11.33676934242259.21985340118408
16508sAMYStriatum-like amygdalar nuclei1.040194392204280.989035964012146
16508STRStriatum20.205075263977115.5146911144257
16508STRdStriatum dorsal region25.190905570983919.322413444519
16508STRvStriatum ventral region22.072991371154816.5173677206039
16508THThalamus6.720220327377326.71288514137268
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3751GO:0001508TASProcessregulation of action potential
3751GO:0005249NASFunctionvoltage-gated potassium channel activity
3751GO:0005515IPIFunctionprotein binding
3751GO:0005515NASFunctionprotein binding
3751GO:0006812IEAProcesscation transport
3751GO:0006813IEAProcesspotassium ion transport
3751GO:0007268TASProcesssynaptic transmission
3751GO:0008076IEAComponentvoltage-gated potassium channel complex
3751GO:0008270IEAFunctionzinc ion binding
3751GO:0009986IEPComponentcell surface
3751GO:0016020IEAComponentmembrane
3751GO:0016021IEAComponentintegral to membrane
3751GO:0030955IEAFunctionpotassium ion binding
3751GO:0043197NASComponentdendritic spine
3751GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-80333NP_079497.2Kv channel interacting protein 4 isoform 1HPRD12184
NP_036413.130820NP_055407.1Kv channel interacting protein 1 isoform 2BIND185410
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3751KCND2_HUMANQ9NZV8IPR005821Ion_transIon transport
3751KCND2_HUMANQ9NZV8IPR013099Ion_trans_2_bacIon transport 2, bacterial
3751KCND2_HUMANQ9NZV8IPR013621Ion_trans_NIon transport N-terminal
3751KCND2_HUMANQ9NZV8IPR001622K+channel_poreK+ channel, pore region
3751KCND2_HUMANQ9NZV8IPR004054KV41channelKv4.1 voltage-gated K+ channel
3751KCND2_HUMANQ9NZV8IPR004055KV42channelKv4.2 voltage-gated K+ channel
3751KCND2_HUMANQ9NZV8IPR004056KV43channelKv4.3 voltage-gated K+ channel
3751KCND2_HUMANQ9NZV8IPR003971Kv9_channelKv9 voltage-gated K+ channel
3751KCND2_HUMANQ9NZV8IPR003968Kv_channelKv channel
3751KCND2_HUMANQ9NZV8IPR003091K_channelVoltage-dependent potassium channel
3751KCND2_HUMANQ9NZV8IPR003131K_tetraK+ channel tetramerisation
3751KCND2_HUMANQ9NZV8IPR005820M+channel_nlgCation channel, non-ligand gated
3751KCND2_HUMANQ9NZV8IPR003973Shab_channelShab voltage-gated K+ channel
3751KCND2_HUMANQ9NZV8IPR003975Shal_channelShal voltage-gated K+ channel
3751KCND2_HUMANQ9NZV8IPR003974Shaw_channelShaw voltage-gated K+ channel

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