Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:375790
Official Symbol:AGRN
Other Aliases:FLJ45064
See related:HGNC:329|MIM:103320|HPRD:10550
Chromosome:1
Location:1p36.33
Gene Description:agrin
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0604
ORGANISM:human
Entrez Gene ID:375790
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:25592
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11603CBCerebellum6.035216808319096.13705110549927
11603CTXCerebral cortex42.956523895263731.1620905399323
11603HIPHippocampal region31.565924644470248.9742884635925
11603HPFHippocampal formation32.57068634033237.1948637962341
11603HYHypothalamus25.086814641952517.7473537921906
11603LSXLateral septal complex39.045189142227228.2385092973709
11603MBMidbrain32.058088302612326.8499717712402
11603MYMedulla35.896852493286134.3529114723206
11603OLFOlfactory bulb45.038231849670436.4557111263275
11603PPons28.008653163909925.2996988296509
11603PALPallidum17.968159317970313.1937940716743
11603RHPRetrohippocampal region33.892962932586726.79860496521
11603sAMYStriatum-like amygdalar nuclei26.817944884300218.4934427142143
11603STRStriatum16.976851820945711.7520817518234
11603STRdStriatum dorsal region10.52972823381427.31691998243332
11603STRvStriatum ventral region24.10807359218615.4064996242523
11603THThalamus49.658045768737838.3023085594177
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
375790GO:0005200TASFunctionstructural constituent of cytoskeleton
375790GO:0005554NDFunctionmolecular function unknown
375790GO:0005605IDAComponentbasal lamina
375790GO:0005605TASComponentbasal lamina
375790GO:0007165TASProcesssignal transduction
375790GO:0007213TASProcessacetylcholine receptor signaling, muscarinic pathway
375790GO:0007268NASProcesssynaptic transmission
375790GO:0043113IDAProcessreceptor clustering
375790GO:0043113IMPProcessreceptor clustering
375790GO:0043236TASFunctionlaminin binding
375790GO:0045162TASProcessclustering of voltage-gated sodium channels
375790GO:0050808TASProcesssynapse organization and biogenesis
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
375790AGRN_HUMANO00468IPR004850Agrin_NtAAgrin NtA
375790AGRN_HUMANO00468IPR001438EGF_2EGF-like, type 2
375790AGRN_HUMANO00468IPR000742EGF_3EGF-like, type 3
375790AGRN_HUMANO00468IPR002049EGF_lamininEGF-like, laminin
375790AGRN_HUMANO00468IPR006209EGF_likeEGF-like
375790AGRN_HUMANO00468IPR013032EGF_like_regEGF-like region
375790AGRN_HUMANO00468IPR001791Laminin_GLaminin G
375790AGRN_HUMANO00468IPR012679Laminin_G_1Laminin G, subdomain 1
375790AGRN_HUMANO00468IPR012680Laminin_G_2Laminin G, subdomain 2
375790AGRN_HUMANO00468IPR001239Prot_inh_Kazal-mProteinase inhibitor I1, Kazal metazoa
375790AGRN_HUMANO00468IPR002350Prot_inh_KazalProteinase inhibitor I1, Kazal
375790AGRN_HUMANO00468IPR011497Prot_Inh_Kazal_2Protease inhibitor, Kazal-type
375790AGRN_HUMANO00468IPR000694PRO_richProline-rich region
375790AGRN_HUMANO00468IPR000082SEASEA
375790AGRN_HUMANO00468IPR001455SirA_likeSirA-like

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