Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3763
Official Symbol:KCNJ6
Other Aliases:BIR1|GIRK2|KATP2|KCNJ7|KIR3.2|MGC126596|hiGIRK2
See related:HGNC:6267|MIM:600877|HPRD:02929
Chromosome:21
Location:21q22.1|21q22.13-q22.2
Gene Description:potassium inwardly-rectifying channel, subfamily J, member 6
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0125
ORGANISM:human
Entrez Gene ID:3763
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:2.65 :: 3.03 :: 3.58 :: 1.72 :: -2.28 :: -2.65 :: -0.55
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
16522CBCerebellum43.720492362976133.5627241134644
16522CTXCerebral cortex91.323963165283281.8724784851074
16522HIPHippocampal region96.9314880371094100.0
16522HPFHippocampal formation85.0028762817383100.0
16522HYHypothalamus14.679475307464611.9024558067322
16522LSXLateral septal complex40.148573875427229.2553243637085
16522MBMidbrain14.890934944152817.1238117218018
16522MYMedulla17.833333015441918.1376981735229
16522OLFOlfactory bulb93.694587707519581.7580299377441
16522PPons20.546374320983923.3683795928955
16522PALPallidum8.874538421630867.6136474609375
16522RHPRetrohippocampal region60.244146347045954.2281494140625
16522sAMYStriatum-like amygdalar nuclei27.075103759765620.3200283050537
16522STRStriatum10.15779066085828.4762589931488
16522STRdStriatum dorsal region5.222603440284735.35705184936523
16522STRvStriatum ventral region7.57395291328435.38573217391968
16522THThalamus21.21504878997820.2001304626465
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3763GO:0005244IEAFunctionvoltage-gated ion channel activity
3763GO:0005267IEAFunctionpotassium channel activity
3763GO:0006811IEAProcession transport
3763GO:0006813TASProcesspotassium ion transport
3763GO:0008076TASComponentvoltage-gated potassium channel complex
3763GO:0015467TASFunctionG-protein activated inward rectifier potassium channel activity
3763GO:0016020IEAComponentmembrane
3763GO:0016021IEAComponentintegral to membrane
3763GO:0030955IEAFunctionpotassium ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3765NP_004974.2potassium inwardly-rectifying channel subfamily J9HPRD02959
NP_002231.1--G beta gammaHPRD02929
NP_002231.13765-GIRK3HPRD02929
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3763IRK6_HUMANP48051IPR013673IRK_NInward rectifier potassium channel N-terminal
3763IRK6_HUMANP48051IPR001622K+channel_poreK+ channel, pore region
3763IRK6_HUMANP48051IPR013521K+channel_IR_Cr2K+ channel, inward rectifier, conserved region 2
3763IRK6_HUMANP48051IPR003274KIR31_channelKir3.1 inward rectifier K+ channel
3763IRK6_HUMANP48051IPR003275KIR32_channelKir3.2 inward rectifier K+ channel

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