Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3778
Official Symbol:KCNMA1
Other Aliases:BKTM|DKFZp686K1437|KCa1.1|MGC71881|MaxiK|SAKCA|SLO|SLO-ALPHA
See related:HGNC:6284|MIM:600150|HPRD:15967
Chromosome:10
Location:10q22.3
Gene Description:potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0019
ORGANISM:human
Entrez Gene ID:3778
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:16531
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
16532CBCerebellum1.17324399948121.95920550823212
16531CBCerebellum27.9496269226074100.0
16532CTXCerebral cortex0.6260961294174190.898016631603241
16531CTXCerebral cortex100.0100.0
16532HIPHippocampal region0.7321730852127081.03514170646667
16531HIPHippocampal region56.0682754516602100.0
16532HPFHippocampal formation0.5373133420944210.836621344089508
16531HPFHippocampal formation75.4900207519531100.0
16532HYHypothalamus0.07048182934522630.0916464999318123
16531HYHypothalamus6.826824665069586.40935039520264
16532LSXLateral septal complex0.2015238404273990.226526007056236
16531LSXLateral septal complex11.968508720397912.4851503372192
16532MBMidbrain0.2276726365089420.642305433750153
16531MBMidbrain13.461442947387714.6607694625854
16532MYMedulla0.2903275489807130.546766400337219
16531MYMedulla17.277751922607422.1673049926758
16532OLFOlfactory bulb0.554160654544832.01108574867249
16531OLFOlfactory bulb84.0700073242188100.0
16532PPons0.2157537490129470.41295650601387
16531PPons12.680859565734914.9907236099243
16532PALPallidum0.05460840836167340.130398228764534
16531PALPallidum8.097878456115728.21006202697754
16532RHPRetrohippocampal region0.1923332363367080.497985064983368
16531RHPRetrohippocampal region100.0100.0
16532sAMYStriatum-like amygdalar nuclei1.079835653305052.89826130867004
16531sAMYStriatum-like amygdalar nuclei12.670149803161611.9110889434814
16532STRStriatum0.2193911224603650.45506963133812
16531STRStriatum20.706144332885717.0677528381348
16532STRdStriatum dorsal region0.1037994474172590.154535755515099
16531STRdStriatum dorsal region22.287235260009818.0796318054199
16532STRvStriatum ventral region0.1368638426065440.254866391420364
16531STRvStriatum ventral region22.948152542114317.8524684906006
16532THThalamus0.1990773826837540.431019365787506
16531THThalamus84.947540283203197.6703720092773
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3778GO:0000287IEAFunctionmagnesium ion binding
3778GO:0005249IEAFunctionvoltage-gated potassium channel activity
3778GO:0005509IEAFunctioncalcium ion binding
3778GO:0005515IPIFunctionprotein binding
3778GO:0006812IEAProcesscation transport
3778GO:0006813IEAProcesspotassium ion transport
3778GO:0006813NASProcesspotassium ion transport
3778GO:0006936NRProcessmuscle contraction
3778GO:0007268TASProcesssynaptic transmission
3778GO:0007269NRProcessneurotransmitter secretion
3778GO:0008076IEAComponentvoltage-gated potassium channel complex
3778GO:0008076TASComponentvoltage-gated potassium channel complex
3778GO:0015269IEAFunctioncalcium-activated potassium channel activity
3778GO:0015269NASFunctioncalcium-activated potassium channel activity
3778GO:0016020IEAComponentmembrane
3778GO:0016021IEAComponentintegral to membrane
3778GO:0016021NASComponentintegral to membrane
3778GO:0030955IEAFunctionpotassium ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3779NP_004128.1potassium large conductance calcium-activated channel, subfamily M, beta member 1HPRD10358
NP_002238.23779-KCNMB1HPRD15967
NP_002238.25747NP_005598.3PTK2 protein tyrosine kinase 2 isoform bHPRD02859
NP_002238.25747NP_005598.3PTK2 protein tyrosine kinase 2 isoform bHPRD15967
NP_002238.28912NP_066921.2calcium channel, voltage-dependent, alpha 1H subunit isoform aBIND50212
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3778IPR003929BK_channel_alphaCalcium-activated BK potassium channel, alpha subunit
3778IPR000366GPCR_STE2Fungal pheromone mating factor STE2 GPCR
3778IPR003006Ig_MHCImmunoglobulin/major histocompatibility complex
3778IPR005821Ion_transIon transport
3778IPR013099Ion_trans_2_bacIon transport 2, bacterial
3778IPR013621Ion_trans_NIon transport N-terminal
3778IPR001622K+channel_poreK+ channel, pore region
3778IPR003091K_channelVoltage-dependent potassium channel
3778IPR005820M+channel_nlgCation channel, non-ligand gated
3778IPR002052N6_MtaseN-6 Adenine-specific DNA methylase

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