Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:378
Official Symbol:ARF4
Other Aliases:-
See related:HGNC:655|MIM:601177|HPRD:03107
Chromosome:3
Location:3p21.2-p21.1
Gene Description:ADP-ribosylation factor 4
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0183
ORGANISM:human
Entrez Gene ID:378
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15312160
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11843CBCerebellum26.162548065185545.8137397766113
11843CTXCerebral cortex87.365463256835976.7614593505859
11843HIPHippocampal region49.893638610839886.1657485961914
11843HPFHippocampal formation56.148113250732474.5580749511719
11843HYHypothalamus37.319313049316433.0599975585938
11843LSXLateral septal complex70.111312866210961.5897827148438
11843MBMidbrain40.707557678222738.554370880127
11843MYMedulla51.09387969970761.9939613342285
11843OLFOlfactory bulb69.860336303710965.9918746948242
11843PPons43.875133514404349.0618019104004
11843PALPallidum43.583980560302740.7824058532715
11843RHPRetrohippocampal region67.900703430175860.2564735412598
11843sAMYStriatum-like amygdalar nuclei69.461585998535254.3053970336914
11843STRStriatum64.764175415039150.7458572387695
11843STRdStriatum dorsal region63.605812072753949.3939399719238
11843STRvStriatum ventral region67.495185852050849.9552993774414
11843THThalamus60.429622650146557.7927093505859
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
378GO:0000166IEAFunctionnucleotide binding
378GO:0003924TASFunctionGTPase activity
378GO:0005525IEAFunctionGTP binding
378GO:0005622IEAComponentintracellular
378GO:0005795IEAComponentGolgi stack
378GO:0006364IEAProcessrRNA processing
378GO:0006888IEAProcessER to Golgi vesicle-mediated transport
378GO:0007264IEAProcesssmall GTPase mediated signal transduction
378GO:0008047NRFunctionenzyme activator activity
378GO:0015031IEAProcessprotein transport
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_001651.11956NP_005219.1epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)HPRD03107
NP_001651.11956NP_005219.1epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)HPRD00579
NP_001651.19727NP_055515.1rab11-family interacting protein 3HPRD18521
NP_001651.19727NP_055515.1rab11-family interacting protein 3HPRD18521
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
378ARF4_HUMANP18085IPR006688ARFADP-ribosylation factor
378ARF4_HUMANP18085IPR006689ARF/SARARF/SAR superfamily
378ARF4_HUMANP18085IPR013753RasRas
378ARF4_HUMANP18085IPR001806Ras_trnsfrmngRas GTPase

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