Knowledgebase for Addiction-Related Genes
Home | Score | Chromosome | Pathway | Advanced Search | BLAST Search | Downloads | Publications | FAQ & Help |   

KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3875
Official Symbol:KRT18
Other Aliases:CYK18|K18
See related:HGNC:6430|MIM:148070|HPRD:01020
Chromosome:12
Location:12q13
Gene Description:keratin 18
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0214
ORGANISM:human
Entrez Gene ID:3875
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Downregulated
Fold Change:At least 2-folds difference
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
16668CBCerebellum0.00.0
16668CTXCerebral cortex0.00.0
16668HIPHippocampal region0.00.0
16668HPFHippocampal formation0.00.0
16668HYHypothalamus0.00.0
16668LSXLateral septal complex0.00.0
16668MBMidbrain0.00.0
16668MYMedulla0.00.0
16668OLFOlfactory bulb0.00.0
16668PPons0.00.0
16668PALPallidum0.00.0
16668RHPRetrohippocampal region0.00.0
16668sAMYStriatum-like amygdalar nuclei0.00.0
16668STRStriatum0.00.0
16668STRdStriatum dorsal region0.00.0
16668STRvStriatum ventral region0.00.0
16668THThalamus0.00.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3875GO:0005200NRFunctionstructural constituent of cytoskeleton
3875GO:0005515IPIFunctionprotein binding
3875GO:0005882TASComponentintermediate filament
3875GO:0009653TASProcessmorphogenesis
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5310NP_000287.2polycystin 1 isoform 2 precursorHPRD03203
-7133NP_001057.1tumor necrosis factor receptor 2 precursorHPRD01862
-7529NP_003395.1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptideHPRD03184
-7533NP_003396.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, eta polypeptideHPRD00215
-7534NP_003397.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptideHPRD03183
-8717NP_003780.1TNFRSF1A-associated via death domain isoform 1HPRD04610
-5318NP_004563.1plakophilin 2 isoform 2bHPRD04177
-7531NP_006752.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptideHPRD05457
-11187NP_009114.1plakophilin 3BIND259672
-7532NP_036611.2tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptideHPRD05639
-9191NP_127491.1death effector domain-containing proteinHPRD06022
-85415NP_149094.2rhophilin-like proteinHPRD10192
-10049NP_490647.1DnaJ (Hsp40) homolog, subfamily B, member 6 isoform aHPRD07107
NP_000215.1--hsp70HPRD01020
NP_000215.1--TATHPRD01020
NP_000215.1--Tc85-11HPRD01020
NP_000215.1--Adenovirus proteinaseHPRD01020
NP_000215.15581-Protein kinase C epsilonHPRD01020
NP_000215.17529-14-3-3 BetaHPRD01020
NP_000215.17531-14-3-3 epsilonHPRD01020
NP_000215.17532-14-3-3 gammaHPRD01020
NP_000215.17533-14-3-3 EtaHPRD01020
NP_000215.17534-14-3-3 zetaHPRD01020
NP_000215.17133-Tumor necrosis factor receptor 2HPRD01020
NP_000215.15318-Plakophilin 2HPRD01020
NP_000215.110049-DNAJB6HPRD01020
NP_000215.15310-Polycystin 1HPRD01020
NP_000215.18717-TRADDHPRD01020
NP_000215.19191-DEDDHPRD01020
NP_000215.15411AAB48304.1Human desmosome associated protein pinin mRNA, and translated productsHPRD01020
NP_000215.15411AAB48304.1Human desmosome associated protein pinin mRNA, and translated productsHPRD04401
NP_000215.18717NP_003780.1TNFRSF1A-associated via death domain isoform 1BIND12823
NP_000215.17399NP_996816.1usherin isoform BHPRD01020
NP_000215.17399NP_996816.1usherin isoform BHPRD09759
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3875K1C18_HUMANP05783IPR001664IFIntermediate filament protein
3875K1C18_HUMANP05783IPR002957Keratin_IKeratin, type I
3875K1C18_HUMANP05783IPR003054Keratin_IIType II keratin

© Center for Bioinformatics(CBI), Peking University
Any Comments and suggestions to : KARG GROUP.