Knowledgebase for Addiction-Related Genes
Home | Score | Chromosome | Pathway | Advanced Search | BLAST Search | Downloads | Publications | FAQ & Help |   

KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:397
Official Symbol:ARHGDIB
Other Aliases:D4|GDIA2|GDID4|LYGDI|Ly-GDI|RAP1GN1
See related:HGNC:679|MIM:602843|HPRD:04162
Chromosome:12
Location:12p12.3
Gene Description:Rho GDP dissociation inhibitor (GDI) beta
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0199
ORGANISM:human
Entrez Gene ID:397
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Downregulated
Fold Change:At least 2-folds difference
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11857CBCerebellum100.0100.0
11857CTXCerebral cortex100.0100.0
11857HIPHippocampal region100.0100.0
11857HPFHippocampal formation100.0100.0
11857HYHypothalamus100.0100.0
11857LSXLateral septal complex100.0100.0
11857MBMidbrain100.0100.0
11857MYMedulla95.0323867797852100.0
11857OLFOlfactory bulb100.0100.0
11857PPons99.0976638793945100.0
11857PALPallidum100.0100.0
11857RHPRetrohippocampal region100.0100.0
11857sAMYStriatum-like amygdalar nuclei100.0100.0
11857STRStriatum100.0100.0
11857STRdStriatum dorsal region100.0100.0
11857STRvStriatum ventral region100.0100.0
11857THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
397GO:0005094TASFunctionRho GDP-dissociation inhibitor activity
397GO:0005096IEAFunctionGTPase activator activity
397GO:0005737TASComponentcytoplasm
397GO:0005856TASComponentcytoskeleton
397GO:0006928TASProcesscell motility
397GO:0006955TASProcessimmune response
397GO:0007162TASProcessnegative regulation of cell adhesion
397GO:0007266TASProcessRho protein signal transduction
397GO:0007275TASProcessdevelopment
397GO:0016023TASComponentcytoplasmic membrane-bound vesicle
397GO:0030036TASProcessactin cytoskeleton organization and biogenesis
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-998NP_001782.1cell division cycle 42 isoform 1HPRD00309
-998NP_001782.1cell division cycle 42 isoform 1HPRD00309
-5880NP_002863.1ras-related C3 botulinum toxin substrate 2HPRD03628
-7430NP_003370.2villin 2HPRD00475
-399NP_004301.1ras homolog gene family, member HHPRD03616
-7409NP_005419.2vav 1 oncogeneHPRD01284
-5879NP_061485.1ras-related C3 botulinum toxin substrate 1 isoform Rac1bHPRD03627
-5879NP_061485.1ras-related C3 botulinum toxin substrate 1 isoform Rac1bHPRD03627
NP_001166.17430-EzrinHPRD04162
NP_001166.15879-Ras related C3 botulinum toxin substrate 1HPRD04162
NP_001166.1998-CDC42HPRD04162
NP_001166.15880-Ras related C3 botulinum toxin substrate 2HPRD04162
NP_001166.17409-VAV1HPRD04162
NP_001166.1399-Ras homolog gene family, member HHPRD04162
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
397GDIS_HUMANP52566IPR000406Rho_GDIRHO protein GDP dissociation inhibitor

© Center for Bioinformatics(CBI), Peking University
Any Comments and suggestions to : KARG GROUP.