Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3984
Official Symbol:LIMK1
Other Aliases:LIMK
See related:HGNC:6613|MIM:601329|HPRD:03210
Chromosome:7
Location:7q11.23
Gene Description:LIM domain kinase 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0395
ORGANISM:human
Entrez Gene ID:3984
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:65172
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
16885CBCerebellum5.8937067985534710.1153583526611
16885CTXCerebral cortex5.450275897979745.29869270324707
16885HIPHippocampal region1.94505584239962.39375805854797
16885HPFHippocampal formation2.235916852951052.45414137840271
16885HYHypothalamus7.610087871551518.05803489685059
16885LSXLateral septal complex1.108861684799191.36532044410706
16885MBMidbrain17.215995788574221.6986904144287
16885MYMedulla35.031517028808658.0522422790527
16885OLFOlfactory bulb1.754929423332212.31076049804688
16885PPons39.720153808593857.9099769592285
16885PALPallidum12.000024795532215.693811416626
16885RHPRetrohippocampal region2.612414598464972.46769571304321
16885sAMYStriatum-like amygdalar nuclei0.9853786826133730.714710652828217
16885STRStriatum1.436822414398191.72094309329987
16885STRdStriatum dorsal region1.420850038528441.67933809757233
16885STRvStriatum ventral region1.829321861267092.3634934425354
16885THThalamus8.8915538787841810.1918678283691
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3984GO:0000166IEAFunctionnucleotide binding
3984GO:0004674TASFunctionprotein serine/threonine kinase activity
3984GO:0004713IEAFunctionprotein-tyrosine kinase activity
3984GO:0005515IPIFunctionprotein binding
3984GO:0005524IEAFunctionATP binding
3984GO:0005737TASComponentcytoplasm
3984GO:0006468TASProcessprotein amino acid phosphorylation
3984GO:0006928NRProcesscell motility
3984GO:0007165TASProcesssignal transduction
3984GO:0007266TASProcessRho protein signal transduction
3984GO:0007399TASProcessnervous system development
3984GO:0008270IEAFunctionzinc ion binding
3984GO:0016740IEAFunctiontransferase activity
3984GO:0030036TASProcessactin cytoskeleton organization and biogenesis
3984GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7534NP_003397.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptideHPRD03183
-10298NP_005875.1p21-activated kinase 4 isoform 1HPRD05675
-51132NP_899196.1ring finger protein 12HPRD02304
NP_002305.1--pp140HPRD03210
NP_002305.151132-Ring finger protein 12HPRD03210
NP_002305.110298-PAK4HPRD03210
NP_002305.110298-p21 activated kinase 4HPRD03210
NP_002305.17534-14-3-3 zetaHPRD03210
NP_002305.15829-PaxillinHPRD03210
NP_002305.185464--BIND209430
NP_002305.15058AAC24716.1Homo sapiens p21 activated kinase 1B (PAK1B) mRNA, complete cds.HPRD03210
NP_002305.15058AAC24716.1Homo sapiens p21 activated kinase 1B (PAK1B) mRNA, complete cds.HPRD03995
NP_002305.13985AAH13051.1LIM domain kinase 2, isoform 1HPRD03210
NP_002305.13985AAH13051.1LIM domain kinase 2, isoform 1HPRD03585
NP_002305.154434BAB84115.1hSSH-1SBIND214535
NP_002305.13984NP_002305.1LIM domain kinase 1HPRD03210
NP_002305.19113NP_004681.1LATS homolog 1BIND146457
NP_002305.16093NP_005397.1Rho-associated, coiled-coil containing protein kinase 1HPRD03210
NP_002305.16093NP_005397.1Rho-associated, coiled-coil containing protein kinase 1HPRD03414
NP_002305.110298NP_005875.1p21-activated kinase 4 isoform 1BIND209436
NP_002305.154961NP_060746.2slingshot homolog 3 isoform 2BIND209431
NP_002305.154434NP_061857.2slingshot homolog 1BIND214538
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3984LIMK1_HUMANP53667IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
3984LIMK1_HUMANP53667IPR001781LIM_Zn_bdLIM, zinc-binding
3984LIMK1_HUMANP53667IPR001478PDZPDZ/DHR/GLGF
3984LIMK1_HUMANP53667IPR000719Prot_kinaseProtein kinase
3984LIMK1_HUMANP53667IPR001245Tyr_pkinaseTyrosine protein kinase
3984LIMK1_HUMANP53667IPR013695WAKWall-associated kinase

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