Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4005
Official Symbol:LMO2
Other Aliases:RBTN2|RBTNL1|RHOM2|TTG2
See related:HGNC:6642|MIM:180385|HPRD:01586
Chromosome:11
Location:11p13
Gene Description:LIM domain only 2 (rhombotin-like 1)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0881
ORGANISM:human
Entrez Gene ID:4005
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-2.3 :: -1.8 :: -1.7
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
16909CBCerebellum17.813706636428816.4956452846527
16909CTXCerebral cortex2.355307906866071.69985753297806
16909HIPHippocampal region4.774607837200162.28650704026222
16909HPFHippocampal formation4.641541719436652.50449413061142
16909HYHypothalamus3.493872225284582.35899490118027
16909LSXLateral septal complex3.919341444969183.08225882053375
16909MBMidbrain2.450596332550052.24545308947563
16909MYMedulla6.587446689605714.8854393362999
16909OLFOlfactory bulb9.660926103591925.85403352975845
16909PPons5.899632334709175.59400463104248
16909PALPallidum5.355025947093963.18270766735077
16909RHPRetrohippocampal region3.989754855632782.51854985952377
16909sAMYStriatum-like amygdalar nuclei3.965685218572622.82999488711357
16909STRStriatum16.92938500642788.22727024555206
16909STRdStriatum dorsal region21.474823355674710.3813954591751
16909STRvStriatum ventral region20.36785703897488.73299354314804
16909THThalamus2.275083512067791.49019715189934
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4005GO:0005515ISSFunctionprotein binding
4005GO:0005634IEAComponentnucleus
4005GO:0007275TASProcessdevelopment
4005GO:0008270IEAFunctionzinc ion binding
4005GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5932AAH30590.1RBBP8 proteinHPRD04990
-6887NP_005412.1T-cell acute lymphocytic leukemia 2HPRD01735
-4301NP_005927.1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)HPRD01164
-51132NP_899196.1ring finger protein 12HPRD02304
NP_005565.16887-T-Cell acute lymphoblastic leukemia 2HPRD01586
NP_005565.151132-Ring finger protein 12HPRD01586
NP_005565.15932-CTIPHPRD01586
NP_005565.14301-AF6HPRD01586
NP_005565.15932NP_002885.1retinoblastoma binding protein 8 isoform aBIND12727
NP_005565.16886NP_003180.1T-cell acute lymphocytic leukemia 1HPRD01586
NP_005565.16886NP_003180.1T-cell acute lymphocytic leukemia 1HPRD01753
NP_005565.18861NP_003884.1LIM domain binding 1HPRD01586
NP_005565.18861NP_003884.1LIM domain binding 1HPRD09144
NP_005565.15927NP_005047.1retinoblastoma binding protein 2HPRD01586
NP_005565.15927NP_005047.1retinoblastoma binding protein 2HPRD08915
NP_005565.14005NP_005565.1LIM domain only 2HPRD01586
NP_005565.14066NP_005574.2lymphoblastic leukemia derived sequence 1HPRD01586
NP_005565.14066NP_005574.2lymphoblastic leukemia derived sequence 1HPRD01046
NP_005565.14807NP_005589.1nescient helix loop helix 1HPRD01586
NP_005565.14807NP_005589.1nescient helix loop helix 1HPRD01212
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4005RBTN2_HUMANP25791IPR001781LIM_Zn_bdLIM, zinc-binding

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