Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:400745
Official Symbol:SH2D5
Other Aliases:FLJ41242|FLJ41847|FLJ42879
See related:HGNC:28819
Chromosome:1
Location:1p36.12
Gene Description:SH2 domain containing 5
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0928
ORGANISM:human
Entrez Gene ID:400745
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.5 :: 1.6
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
230863CBCerebellum26.797323226928733.6042251586914
230863CTXCerebral cortex100.099.6048126220703
230863HIPHippocampal region66.6524200439453100.0
230863HPFHippocampal formation85.360710144043100.0
230863HYHypothalamus54.839969635009840.8353881835938
230863LSXLateral septal complex100.0100.0
230863MBMidbrain57.238681793212945.9326362609863
230863MYMedulla38.348224639892631.1016883850098
230863OLFOlfactory bulb68.459251403808660.8191566467285
230863PPons42.770652770996134.3995971679688
230863PALPallidum59.708614349365254.729793548584
230863RHPRetrohippocampal region100.0100.0
230863sAMYStriatum-like amygdalar nuclei100.0100.0
230863STRStriatum100.0100.0
230863STRdStriatum dorsal region100.0100.0
230863STRvStriatum ventral region100.0100.0
230863THThalamus53.661941528320343.2233848571777
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
400745GO:0007242IEAProcessintracellular signaling cascade
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
400745IPR013625PTBTensin phosphotyrosine-binding domain
400745IPR006020PTB_PIDPhosphotyrosine interaction region
400745IPR000980SH2SH2 motif

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