Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4034
Official Symbol:LRCH4
Other Aliases:FLJ40101|FLJ46315|LRN|LRRN1|LRRN4|PP14183|SAP25
See related:HGNC:6691|HPRD:10062
Chromosome:7
Location:7q22
Gene Description:leucine-rich repeats and calponin homology (CH) domain containing 4
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0365
ORGANISM:human
Entrez Gene ID:4034
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-2 :: -1.6 :: -2 :: -2.3 :: -1.6 :: -1.6
KARG Evidence 2
KARG ID:EVIM0433
ORGANISM:human
Entrez Gene ID:4034
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:1 :: -1.1 :: -1.2 :: -2.7 :: -1.8
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
231798CBCerebellum5.59835672378547.1969633102417
231798CTXCerebral cortex1.104010581970210.941600263118744
231798HIPHippocampal region3.743641614913944.31359720230103
231798HPFHippocampal formation2.723624229431152.88309860229492
231798HYHypothalamus0.2492121011018750.303090780973434
231798LSXLateral septal complex0.00.0
231798MBMidbrain0.5562815666198730.632982432842255
231798MYMedulla2.593390226364142.84983372688293
231798OLFOlfactory bulb6.630830764770516.44140720367432
231798PPons1.207913637161251.2952481508255
231798PALPallidum0.7614985108375550.814387083053589
231798RHPRetrohippocampal region0.8075528740882870.724664807319641
231798sAMYStriatum-like amygdalar nuclei2.046867609024052.29004216194153
231798STRStriatum1.920712828636172.17458987236023
231798STRdStriatum dorsal region2.018030166625982.61085510253906
231798STRvStriatum ventral region1.980465769767761.44584500789642
231798THThalamus0.7909640073776250.685763955116272
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4034GO:0007399TASProcessnervous system development
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4034LRCH4_HUMANO75427IPR001715Calponin_act_bdCalponin-like actin-binding
4034LRCH4_HUMANO75427IPR001611LRRLeucine-rich repeat
4034LRCH4_HUMANO75427IPR003096SM22_calponinSM22/calponin

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