Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4057
Official Symbol:LTF
Other Aliases:GIG12|HLF2
See related:HGNC:6720|MIM:150210|HPRD:01028
Chromosome:3
Location:3q21-q23
Gene Description:lactotransferrin
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0405
ORGANISM:human
Entrez Gene ID:4057
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:-1.9 :: 2 :: 1.1 :: 1.5 :: -1.3
KARG Evidence 2
KARG ID:EVIM0473
ORGANISM:human
Entrez Gene ID:4057
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:1.5 :: 1.4 :: -1.4 :: -1.2 :: 1.1
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
17002CBCerebellum0.297254443168640.876191675662994
17002CTXCerebral cortex0.2111736685037610.434597223997116
17002HIPHippocampal region0.6688819527626040.696844041347504
17002HPFHippocampal formation1.597540259361271.46993362903595
17002HYHypothalamus3.511087179183965.05228281021118
17002LSXLateral septal complex0.4518330991268160.59070211648941
17002MBMidbrain0.2099154442548750.683806359767914
17002MYMedulla0.2142846882343290.673017799854279
17002OLFOlfactory bulb0.4131750762462620.353348731994629
17002PPons0.4756906926631931.94860279560089
17002PALPallidum0.09228392690420150.0762207955121994
17002RHPRetrohippocampal region3.95369195938113.16419386863708
17002sAMYStriatum-like amygdalar nuclei0.1148260682821270.111431807279587
17002STRStriatum0.1148948520421980.153969943523407
17002STRdStriatum dorsal region0.05980870500206950.105540119111538
17002STRvStriatum ventral region0.1762163788080220.182613030076027
17002THThalamus0.1406605541706090.244074359536171
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4057GO:0004252TASFunctionserine-type endopeptidase activity
4057GO:0005615NRComponentextracellular space
4057GO:0006811IEAProcession transport
4057GO:0006826IEAProcessiron ion transport
4057GO:0006879IEAProcessiron ion homeostasis
4057GO:0006959TASProcesshumoral immune response
4057GO:0008199IEAFunctionferric iron binding
4057GO:0008233IEAFunctionpeptidase activity
4057GO:0042742IEAProcessdefense response to bacteria
4057GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NC_000003.9---BIND216622
NP_002334.1--PHA-activated lactotransferrin receptorHPRD01028
NP_002334.1--CalmodulinHPRD01028
NP_002334.1--Pancreatic carboxylester hydrolaseHPRD01028
NP_002334.1--MG2HPRD01028
NP_002334.14069NP_000230.1lysozyme precursorHPRD01028
NP_002334.14069NP_000230.1lysozyme precursorHPRD01085
NP_002334.155600NP_060095.2intelectinHPRD17165
NP_002334.14589NP_689504.1mucin 7, salivaryHPRD11759
NP_002334.2-CAA43793.1JK1-fullBIND183212
NP_002334.2-CAA43793.1JK1-fullBIND185196
NP_002334.2951475NP_671491.1polyproteinBIND185382
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4057TRFL_HUMANP02788IPR001156Peptidase_S60Peptidase S60, transferrin lactoferrin

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