Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4060
Official Symbol:LUM
Other Aliases:LDC|SLRR2D
See related:HGNC:6724|MIM:600616|HPRD:02793
Chromosome:12
Location:12q21.3-q22
Gene Description:lumican
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0215
ORGANISM:human
Entrez Gene ID:4060
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Upregulated
Fold Change:At least 2-folds difference
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
17022CBCerebellum2.497436761856085.8334584236145
17022CTXCerebral cortex6.195828914642335.3507285118103
17022HIPHippocampal region5.25795173645027.75329160690308
17022HPFHippocampal formation4.9313166141516.30261135101318
17022HYHypothalamus2.09179008007052.59381783008575
17022LSXLateral septal complex3.956811428070074.57176446914673
17022MBMidbrain2.321914672851563.80679333209991
17022MYMedulla2.952835619449625.65800857543945
17022OLFOlfactory bulb5.725305676460274.52361416816711
17022PPons2.358820438385013.96151065826416
17022PALPallidum4.39389213919644.21538522839546
17022RHPRetrohippocampal region4.21939909458164.07824015617371
17022sAMYStriatum-like amygdalar nuclei5.13089105486874.59872615337372
17022STRStriatum3.027224421501162.42890614271164
17022STRdStriatum dorsal region2.662251830101011.96534743905067
17022STRvStriatum ventral region2.586076915264131.78524962067604
17022THThalamus5.650599658489236.66502320766449
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4060GO:0005201NASFunctionextracellular matrix structural constituent
4060GO:0005518IDAFunctioncollagen binding
4060GO:0005578TASComponentextracellular matrix (sensu Metazoa)
4060GO:0005583IDAComponentfibrillar collagen
4060GO:0007601TASProcessvisual perception
4060GO:0030199NASProcesscollagen fibril organization
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_002336.1--CollagenHPRD02793
NP_002336.1--AggrecanHPRD02793
NP_002336.14323NP_004986.1matrix metalloproteinase 14 preproproteinHPRD02856
NP_002336.14323NP_004986.1matrix metalloproteinase 14 preproproteinHPRD02793
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4060LUM_HUMANP51884IPR001611LRRLeucine-rich repeat
4060LUM_HUMANP51884IPR000372LRR_cys_NLeucine-rich repeat, cysteine-rich flanking region, N-terminal
4060LUM_HUMANP51884IPR003591LRR_typLeucine-rich repeat, typical subtype

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