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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry

For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information Gene ID: 4069 Official Symbol: LYZ Other Aliases: - See related: HGNC:6740|MIM:153450|HPRD:01085 Chromosome: 12 Location: 12q15 Gene Description: lysozyme (renal amyloidosis) Gene type: protein-coding Gene Structure: Genomic Context: KARG Evidence 1 KARG ID: EVIC0376 ORGANISM: human Entrez Gene ID: 4069 Evidence Type: Mapping from rat Evidence ID Type: Entrez Gene Evidence ID: 25211 Addiction Drug: Addiction Drug Detail: Addiction Brain Area: Drug Effects: Fold Change: KARG Evidence 2 KARG ID: EVIM0953 ORGANISM: human Entrez Gene ID: 4069 Evidence Type: Microarray Evidence ID Type: PUBMED Evidence ID: 11141048 Addiction Drug: ALCOHOL Addiction Drug Detail: ALCOHOL ABUSE Addiction Brain Area: Frontal Cortex Drug Effects: Downregulated Fold Change: -1.6 :: -2.5 Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas) Mouse Entrez Gene ID Brain Region Brain Region Detail Expression Level Expression Density 17105 CB Cerebellum 1.9373379945755 6.02956247329712 77397 CB Cerebellum 3.17286229133606 4.12975549697876 17110 CB Cerebellum 7.62753760814667 12.964209318161 77397 CTX Cerebral cortex 0.625334799289703 0.648368895053864 17105 CTX Cerebral cortex 3.78402352333069 4.62433910369873 17110 CTX Cerebral cortex 3.98969596624374 4.66230118274689 77397 HIP Hippocampal region 0.50512957572937 0.463042616844177 17105 HIP Hippocampal region 2.61221599578857 4.25836753845215 17110 HIP Hippocampal region 3.84396761655807 5.56461822986603 77397 HPF Hippocampal formation 0.397924661636353 0.441135913133621 17105 HPF Hippocampal formation 3.21001291275024 6.63792896270752 17110 HPF Hippocampal formation 3.75381934642792 4.99498927593231 77397 HY Hypothalamus 0.155866518616676 0.391300231218338 17110 HY Hypothalamus 2.15046334266663 2.87507212162018 17105 HY Hypothalamus 2.49421620368958 3.9994490146637 77397 LSX Lateral septal complex 0.137697219848633 0.397930771112442 17105 LSX Lateral septal complex 2.05370903015137 2.97442150115967 17110 LSX Lateral septal complex 2.8244594335556 3.85264670848846 77397 MB Midbrain 0.848167419433594 1.93932235240936 17105 MB Midbrain 2.2441737651825 6.09350919723511 17110 MB Midbrain 4.18854916095734 6.90104126930237 77397 MY Medulla 0.855095386505127 1.1059558391571 17105 MY Medulla 1.59389972686768 3.8698251247406 17110 MY Medulla 10.0730174779892 13.6633341312408 17105 OLF Olfactory bulb 4.01399564743042 5.57634496688843 77397 OLF Olfactory bulb 4.46913909912109 4.70082521438599 17110 OLF Olfactory bulb 8.70047664642334 8.76270937919617 77397 P Pons 0.320696175098419 0.615885078907013 17105 P Pons 1.9606032371521 4.9012279510498 17110 P Pons 5.36203789710999 7.89853858947754 77397 PAL Pallidum 0.0511872693896294 0.0431036874651909 17105 PAL Pallidum 1.98118162155151 2.8036413192749 17110 PAL Pallidum 2.55664050579071 3.46492552757263 77397 RHP Retrohippocampal region 0.194646582007408 0.327808022499084 17110 RHP Retrohippocampal region 3.51807898283005 4.07770866155624 17105 RHP Retrohippocampal region 3.87693071365356 8.86076259613037 77397 sAMY Striatum-like amygdalar nuclei 0.0766932889819145 0.148567035794258 17110 sAMY Striatum-like amygdalar nuclei 3.08793318271637 4.40932536125183 17105 sAMY Striatum-like amygdalar nuclei 4.92880868911743 9.2091588973999 77397 STR Striatum 0.232808902859688 0.283734381198883 17105 STR Striatum 2.28635954856873 3.18385100364685 17110 STR Striatum 3.04868042469025 3.61018073558807 77397 STRd Striatum dorsal region 0.242318466305733 0.313184529542923 17105 STRd Striatum dorsal region 2.19817495346069 3.05529069900513 17110 STRd Striatum dorsal region 2.8193564414978 3.58940327167511 77397 STRv Striatum ventral region 0.301034688949585 0.258616387844086 17105 STRv Striatum ventral region 1.91396260261536 2.1446521282196 17110 STRv Striatum ventral region 3.75853252410889 3.07889503240585 77397 TH Thalamus 0.256241202354431 0.335321098566055 17105 TH Thalamus 2.62004804611206 4.13396263122559 17110 TH Thalamus 4.64548349380493 6.32116985321045 Gene Ontology Gene ID GO ID Evidence GO Type GO Description 4069 GO:0003796 IEA Function lysozyme activity 4069 GO:0005576 IEA Component extracellular region 4069 GO:0005975 IEA Process carbohydrate metabolism 4069 GO:0016798 IEA Function hydrolase activity, acting on glycosyl bonds 4069 GO:0016998 IEA Process cell wall catabolism 4069 GO:0019835 IEA Process cytolysis 4069 GO:0042742 IEA Process defense response to bacteria Interaction Information Gene Product ID Interactant Gene ID Interactant Gene Product ID Interactant Gene Product Name Source Source ID Domain Information Gene ID Uniprot/Swissprot ID Uniprot/Swissprot ACC Interpro ID Interpro Short Description Interpro Long Description 4069 LYSC_HUMAN P61626 IPR000974 Glyco_hydro_22Ly Glycoside hydrolase, family 22, lysozyme 4069 LYSC_HUMAN P61626 IPR001916 Glyco_hydro_22 Glycoside hydrolase, family 22 4069 LYSC_HUMAN P61626 IPR000545 Lactalbumin Lactalbumin © Center for Bioinformatics(CBI), Peking University Any Comments and suggestions to : KARG GROUP.