Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4069
Official Symbol:LYZ
Other Aliases:-
See related:HGNC:6740|MIM:153450|HPRD:01085
Chromosome:12
Location:12q15
Gene Description:lysozyme (renal amyloidosis)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0376
ORGANISM:human
Entrez Gene ID:4069
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:25211
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0953
ORGANISM:human
Entrez Gene ID:4069
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.6 :: -2.5
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
17105CBCerebellum1.93733799457556.02956247329712
77397CBCerebellum3.172862291336064.12975549697876
17110CBCerebellum7.6275376081466712.964209318161
77397CTXCerebral cortex0.6253347992897030.648368895053864
17105CTXCerebral cortex3.784023523330694.62433910369873
17110CTXCerebral cortex3.989695966243744.66230118274689
77397HIPHippocampal region0.505129575729370.463042616844177
17105HIPHippocampal region2.612215995788574.25836753845215
17110HIPHippocampal region3.843967616558075.56461822986603
77397HPFHippocampal formation0.3979246616363530.441135913133621
17105HPFHippocampal formation3.210012912750246.63792896270752
17110HPFHippocampal formation3.753819346427924.99498927593231
77397HYHypothalamus0.1558665186166760.391300231218338
17110HYHypothalamus2.150463342666632.87507212162018
17105HYHypothalamus2.494216203689583.9994490146637
77397LSXLateral septal complex0.1376972198486330.397930771112442
17105LSXLateral septal complex2.053709030151372.97442150115967
17110LSXLateral septal complex2.82445943355563.85264670848846
77397MBMidbrain0.8481674194335941.93932235240936
17105MBMidbrain2.24417376518256.09350919723511
17110MBMidbrain4.188549160957346.90104126930237
77397MYMedulla0.8550953865051271.1059558391571
17105MYMedulla1.593899726867683.8698251247406
17110MYMedulla10.073017477989213.6633341312408
17105OLFOlfactory bulb4.013995647430425.57634496688843
77397OLFOlfactory bulb4.469139099121094.70082521438599
17110OLFOlfactory bulb8.700476646423348.76270937919617
77397PPons0.3206961750984190.615885078907013
17105PPons1.96060323715214.9012279510498
17110PPons5.362037897109997.89853858947754
77397PALPallidum0.05118726938962940.0431036874651909
17105PALPallidum1.981181621551512.8036413192749
17110PALPallidum2.556640505790713.46492552757263
77397RHPRetrohippocampal region0.1946465820074080.327808022499084
17110RHPRetrohippocampal region3.518078982830054.07770866155624
17105RHPRetrohippocampal region3.876930713653568.86076259613037
77397sAMYStriatum-like amygdalar nuclei0.07669328898191450.148567035794258
17110sAMYStriatum-like amygdalar nuclei3.087933182716374.40932536125183
17105sAMYStriatum-like amygdalar nuclei4.928808689117439.2091588973999
77397STRStriatum0.2328089028596880.283734381198883
17105STRStriatum2.286359548568733.18385100364685
17110STRStriatum3.048680424690253.61018073558807
77397STRdStriatum dorsal region0.2423184663057330.313184529542923
17105STRdStriatum dorsal region2.198174953460693.05529069900513
17110STRdStriatum dorsal region2.81935644149783.58940327167511
77397STRvStriatum ventral region0.3010346889495850.258616387844086
17105STRvStriatum ventral region1.913962602615362.1446521282196
17110STRvStriatum ventral region3.758532524108893.07889503240585
77397THThalamus0.2562412023544310.335321098566055
17105THThalamus2.620048046112064.13396263122559
17110THThalamus4.645483493804936.32116985321045
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4069GO:0003796IEAFunctionlysozyme activity
4069GO:0005576IEAComponentextracellular region
4069GO:0005975IEAProcesscarbohydrate metabolism
4069GO:0016798IEAFunctionhydrolase activity, acting on glycosyl bonds
4069GO:0016998IEAProcesscell wall catabolism
4069GO:0019835IEAProcesscytolysis
4069GO:0042742IEAProcessdefense response to bacteria
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4069LYSC_HUMANP61626IPR000974Glyco_hydro_22LyGlycoside hydrolase, family 22, lysozyme
4069LYSC_HUMANP61626IPR001916Glyco_hydro_22Glycoside hydrolase, family 22
4069LYSC_HUMANP61626IPR000545LactalbuminLactalbumin

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