Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:409
Official Symbol:ARRB2
Other Aliases:ARB2|ARR2|DKFZp686L0365
See related:HGNC:712|MIM:107941|HPRD:00147
Chromosome:17
Location:17p13
Gene Description:arrestin, beta 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0541
ORGANISM:human
Entrez Gene ID:409
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:25388
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
216869CBCerebellum86.4070434570312100.0
216869CTXCerebral cortex100.0100.0
216869HIPHippocampal region100.0100.0
216869HPFHippocampal formation100.0100.0
216869HYHypothalamus100.0100.0
216869LSXLateral septal complex100.0100.0
216869MBMidbrain100.0100.0
216869MYMedulla100.0100.0
216869OLFOlfactory bulb100.0100.0
216869PPons100.0100.0
216869PALPallidum98.574539184570391.7766342163086
216869RHPRetrohippocampal region100.0100.0
216869sAMYStriatum-like amygdalar nuclei100.0100.0
216869STRStriatum86.591346740722764.5782241821289
216869STRdStriatum dorsal region73.005538940429753.4528388977051
216869STRvStriatum ventral region93.755828857421964.5849685668945
216869THThalamus100.090.6409149169922
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
409GO:0005634IEAComponentnucleus
409GO:0005737TASComponentcytoplasm
409GO:0005886TASComponentplasma membrane
409GO:0007165IEAProcesssignal transduction
409GO:0007600IEAProcesssensory perception
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-4985NP_000902.2opioid receptor, delta 1HPRD01308
-4193NP_002383.1mouse double minute 2 homolog isoform MDM2HPRD01272
-4923NP_002522.1neurotensin receptor 1HPRD01218
-6416NP_003001.1mitogen-activated protein kinase kinase 4HPRD03213
-6608NP_005622.1smoothenedBIND182816
-4217NP_005914.1mitogen-activated protein kinase kinase kinase 5HPRD03904
-9266NP_059431.1pleckstrin homology, Sec7 and coiled/coil domains 2 isoform 1HPRD03925
-5602NP_620448.1mitogen-activated protein kinase 10 isoform 2HPRD04207
NP_004304.1--ClathrinHPRD00147
NP_004304.1--Neurotensin 1HPRD00147
NP_004304.1--Thyrotropin-releasing hormoneHPRD00147
NP_004304.15602-JNK3HPRD00147
NP_004304.16416-MAP2K4HPRD00147
NP_004304.14985-Opioid receptorHPRD00147
NP_004304.14923-Neurotensin receptor 1HPRD00147
NP_004304.15021-OXTRHPRD00147
NP_004304.15021-Oxytocin receptor OT-RHPRD00147
NP_004304.14217-ASK1HPRD00147
NP_004304.19266-Cytohesin 2HPRD00147
NP_004304.14193-Oncoprotein Mdm2HPRD00147
NP_004304.15144AAC00069.1Homo sapiens cAMP-specific phosphodiesterase PDE4D5 (PDE4D) mRNA, complete cds.BIND146087
NP_004304.1554NP_000045.1arginine vasopressin receptor 2HPRD00147
NP_004304.1554NP_000045.1arginine vasopressin receptor 2HPRD02368
NP_004304.15724NP_000943.1platelet-activating factor receptorHPRD00147
NP_004304.15724NP_000943.1platelet-activating factor receptorHPRD00147
NP_004304.16553NP_004585.1solute carrier family 9 (sodium/hydrogen exchanger), isoform 5BIND262279
NP_004304.11213NP_004850.1clathrin heavy chain 1HPRD00147
NP_004304.14922NP_006174.1neurotensin/neuromedin N preproproteinHPRD00147
NP_004304.15900NP_006257.1ral guanine nucleotide dissociation stimulatorHPRD00147
NP_004304.15900NP_006257.1ral guanine nucleotide dissociation stimulatorHPRD03371
NP_004304.17200NP_009048.1thyrotropin-releasing hormoneHPRD00147
NP_004304.14792NP_065390.1nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alphaBIND133985
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
409IPR000698ArrestinArrestin
409IPR011022Arrestin_CArrestin, C-terminal
409IPR011021Arrestin_NArrestin, N-terminal
409ARRB2_HUMANP32121IPR000698ArrestinArrestin
409ARRB2_HUMANP32121IPR011022Arrestin_CArrestin, C-terminal
409ARRB2_HUMANP32121IPR011021Arrestin_NArrestin, N-terminal

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