Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4099
Official Symbol:MAG
Other Aliases:GMA|S-MAG|SIGLEC-4A|SIGLEC4A
See related:HGNC:6783|MIM:159460|HPRD:01160
Chromosome:19
Location:19q13.1
Gene Description:myelin associated glycoprotein
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0163
ORGANISM:human
Entrez Gene ID:4099
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:16205370
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:superior frontal gyrus
Drug Effects:Downregulated
Fold Change:-
KARG Evidence 2
KARG ID:EVIM0168
ORGANISM:human
Entrez Gene ID:4099
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:16205370
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-
KARG Evidence 3
KARG ID:EVIM0426
ORGANISM:human
Entrez Gene ID:4099
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:-1.2 :: -1.9 :: 2.1 :: 1.6 :: 1.6 :: 1.2
KARG Evidence 4
KARG ID:EVIM0494
ORGANISM:human
Entrez Gene ID:4099
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Upregulated
Fold Change:1.5 :: 1.4 :: -1.1 :: 1.9 :: 1.2
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
17136CBCerebellum92.6422119140625100.0
17136CTXCerebral cortex61.959991455078162.5979499816895
17136HIPHippocampal region66.654624938964883.1017913818359
17136HPFHippocampal formation73.465896606445383.9925308227539
17136HYHypothalamus100.0100.0
17136LSXLateral septal complex100.099.1702041625977
17136MBMidbrain100.0100.0
17136MYMedulla100.0100.0
17136OLFOlfactory bulb56.435150146484460.304859161377
17136PPons100.0100.0
17136PALPallidum100.0100.0
17136RHPRetrohippocampal region82.807708740234483.7983551025391
17136sAMYStriatum-like amygdalar nuclei83.834594726562576.5212478637695
17136STRStriatum95.204284667968894.4234085083008
17136STRdStriatum dorsal region100.0100.0
17136STRvStriatum ventral region61.242778778076255.0500869750977
17136THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4099GO:0004872IEAFunctionreceptor activity
4099GO:0005515IEAFunctionprotein binding
4099GO:0005529IEAFunctionsugar binding
4099GO:0007155IEAProcesscell adhesion
4099GO:0016020IEAComponentmembrane
4099GO:0016021IEAComponentintegral to membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5354NP_000524.2proteolipid protein 1HPRD02321
-4155NP_002376.1myelin basic protein isoform 2HPRD01158
-4131NP_005900.1microtubule-associated protein 1B isoform 1HPRD01139
-65078NP_075380.1reticulon 4 receptor precursorHPRD16123
NP_002352.1--Collagen GHPRD01160
NP_002352.1--Collagen IHPRD01160
NP_002352.1--Collagen IVHPRD01160
NP_002352.1--Collagen IXHPRD01160
NP_002352.1--Collagen VHPRD01160
NP_002352.1--Collagen VIHPRD01160
NP_002352.1--Nogo66 receptorHPRD01160
NP_002352.14131-Microtubule associated protein 1BHPRD01160
NP_002352.14804-Nerve growth factor receptorHPRD01160
NP_002352.165078-Reticulon 4 receptorHPRD01160
NP_002352.14155-Myelin basic proteinHPRD01160
NP_002352.15354-Myelin proteolipid proteinHPRD01160
NP_002352.15621NP_000302.1prion protein preproproteinHPRD01160
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4099IPR013162CD80_C2_set_2CD80-like C2-set immunoglobulin
4099IPR013098I-setImmunoglobulin I-set
4099IPR007110Ig-likeImmunoglobulin-like
4099IPR013151ImmunoglobulinImmunoglobulin
4099IPR009138Neural_cell_adhNeural cell adhesion
4099IPR013106V-setImmunoglobulin V-set
4099MAG_HUMANP20916IPR013162CD80_C2_set_2CD80-like C2-set immunoglobulin
4099MAG_HUMANP20916IPR013098I-setImmunoglobulin I-set
4099MAG_HUMANP20916IPR007110Ig-likeImmunoglobulin-like
4099MAG_HUMANP20916IPR013151ImmunoglobulinImmunoglobulin
4099MAG_HUMANP20916IPR009138Neural_cell_adhNeural cell adhesion
4099MAG_HUMANP20916IPR013106V-setImmunoglobulin V-set

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