Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4118
Official Symbol:MAL
Other Aliases:-
See related:HGNC:6817|MIM:188860|HPRD:01789
Chromosome:2
Location:2cen-q13
Gene Description:mal, T-cell differentiation protein
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0004
ORGANISM:human
Entrez Gene ID:4118
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:17153
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0827
ORGANISM:human
Entrez Gene ID:4118
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-2.3 :: -2.3 :: -2.6 :: -3.5
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
17153CBCerebellum80.5690536499023100.0
17153CTXCerebral cortex66.36266326904384.5372314453125
17153HIPHippocampal region67.0662460327148100.0
17153HPFHippocampal formation75.4398880004883100.0
17153HYHypothalamus100.0100.0
17153LSXLateral septal complex75.203094482421992.7498779296875
17153MBMidbrain100.0100.0
17153MYMedulla100.0100.0
17153OLFOlfactory bulb64.188903808593885.3127212524414
17153PPons100.0100.0
17153PALPallidum100.0100.0
17153RHPRetrohippocampal region88.3392715454102100.0
17153sAMYStriatum-like amygdalar nuclei90.9362182617188100.0
17153STRStriatum96.6916961669922100.0
17153STRdStriatum dorsal region100.0100.0
17153STRvStriatum ventral region66.922019958496181.4325942993164
17153THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4118GO:0001766TASProcesslipid raft polarization
4118GO:0005624TASComponentmembrane fraction
4118GO:0005626TASComponentinsoluble fraction
4118GO:0005768TASComponentendosome
4118GO:0005783IDAComponentendoplasmic reticulum
4118GO:0005887TASComponentintegral to plasma membrane
4118GO:0006917NASProcessinduction of apoptosis
4118GO:0007165TASProcesssignal transduction
4118GO:0007417TASProcesscentral nervous system development
4118GO:0007516TASProcesshemocyte development (sensu Arthropoda)
4118GO:0008289TASFunctionlipid binding
4118GO:0015267TASFunctionchannel or pore class transporter activity
4118GO:0016020IEAComponentmembrane
4118GO:0016324TASComponentapical plasma membrane
4118GO:0016505NASFunctionapoptotic protease activator activity
4118GO:0019911IDAFunctionstructural constituent of myelin sheath
4118GO:0030154TASProcesscell differentiation
4118GO:0042552NASProcessmyelination
4118GO:0042552TASProcessmyelination
4118GO:0045121IDAComponentlipid raft
4118GO:0045176TASProcessapical protein localization
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4118
4118IPR008253MarvelMarvel
4118MAL_HUMANP21145IPR008253MarvelMarvel

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