Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4124
Official Symbol:MAN2A1
Other Aliases:MANA2|MANII
See related:HGNC:6824|MIM:154582|HPRD:01110
Chromosome:5
Location:5q21-q22
Gene Description:mannosidase, alpha, class 2A, member 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0321
ORGANISM:human
Entrez Gene ID:4124
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-0.58
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
17158CBCerebellum11.164029121398912.8520202636719
17158CTXCerebral cortex33.900985717773422.2185306549072
17158HIPHippocampal region16.013061523437514.5064878463745
17158HPFHippocampal formation20.322751998901416.5291576385498
17158HYHypothalamus2.885909080505372.109943151474
17158LSXLateral septal complex11.27013587951666.68724536895752
17158MBMidbrain4.78654241561893.77150130271912
17158MYMedulla11.37800121307379.48266696929932
17158OLFOlfactory bulb19.798624038696313.7918291091919
17158PPons7.203991413116466.50904035568237
17158PALPallidum8.235826492309576.60470819473267
17158RHPRetrohippocampal region28.815916061401420.1918144226074
17158sAMYStriatum-like amygdalar nuclei17.13852119445810.3798313140869
17158STRStriatum20.337415695190412.5248699188232
17158STRdStriatum dorsal region23.6067104339614.8539419174194
17158STRvStriatum ventral region13.74970054626467.95282459259033
17158THThalamus10.00993633270267.53914308547974
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4124GO:0004559IEAFunctionalpha-mannosidase activity
4124GO:0004572TASFunctionmannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
4124GO:0005624NRComponentmembrane fraction
4124GO:0005795IEAComponentGolgi stack
4124GO:0005975IEAProcesscarbohydrate metabolism
4124GO:0006013IEAProcessmannose metabolism
4124GO:0009101NRProcessglycoprotein biosynthesis
4124GO:0016020IEAComponentmembrane
4124GO:0016021IEAComponentintegral to membrane
4124GO:0016798IEAFunctionhydrolase activity, acting on glycosyl bonds
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4124MA2A1_HUMANQ16706IPR000602Glyco_hydro_38Glycoside hydrolase, family 38
4124MA2A1_HUMANQ16706IPR011682Glyco_hydro_38CGlycosyl hydrolases 38, C-terminal

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