Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4131
Official Symbol:MAP1B
Other Aliases:DKFZp686E1099|DKFZp686F1345|FLJ38954|FUTSCH|MAP5
See related:HGNC:6836|MIM:157129|HPRD:01139
Chromosome:5
Location:5q13
Gene Description:microtubule-associated protein 1B
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0394
ORGANISM:human
Entrez Gene ID:4131
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:29456
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0103
ORGANISM:human
Entrez Gene ID:4131
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:2.57 :: 3.66 :: 4.95 :: 2.88 :: -4.07 :: -2.66 :: -3.58
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
17755CBCerebellum100.0100.0
17755CTXCerebral cortex100.0100.0
17755HIPHippocampal region100.0100.0
17755HPFHippocampal formation100.0100.0
17755HYHypothalamus100.0100.0
17755LSXLateral septal complex100.0100.0
17755MBMidbrain100.0100.0
17755MYMedulla100.0100.0
17755OLFOlfactory bulb100.0100.0
17755PPons100.0100.0
17755PALPallidum100.0100.0
17755RHPRetrohippocampal region100.0100.0
17755sAMYStriatum-like amygdalar nuclei100.0100.0
17755STRStriatum100.0100.0
17755STRdStriatum dorsal region100.0100.0
17755STRvStriatum ventral region100.0100.0
17755THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4131GO:0005198NASFunctionstructural molecule activity
4131GO:0005515IPIFunctionprotein binding
4131GO:0005874IEAComponentmicrotubule
4131GO:0005875TASComponentmicrotubule associated complex
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-8655NP_003737.1dynein light chain 1HPRD03334
-8125NP_006296.1acidic (leucine-rich) nuclear phosphoprotein 32 family, member AHPRD09014
-8139NP_071324.1gigaxoninHPRD05647
-5599NP_620637.1mitogen-activated protein kinase 8 isoform 1HPRD03100
NP_005900.1--ActinHPRD01139
NP_005900.1--ANP32AHPRD01139
NP_005900.18139-GigaxoninHPRD01139
NP_005900.15599-JNK1HPRD01139
NP_005900.18125-HLA DR associated protein IHPRD01139
NP_005900.18655-DLC1HPRD01139
NP_005900.18655-Dynein light chain 1HPRD01139
NP_005900.16622NP_000336.1alpha-synuclein isoform NACP140HPRD01227
NP_005900.16622NP_000336.1alpha-synuclein isoform NACP140HPRD01139
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4131MAP1B_HUMANP46821IPR001404Hsp90Heat shock protein Hsp90
4131MAP1B_HUMANP46821IPR000102MAP1B_neuraxinNeuraxin/MAP1B repeat
4131MAP1B_HUMANP46821IPR004168PPAK_motifPPAK motif

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