Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4134
Official Symbol:MAP4
Other Aliases:DKFZp779A1753|MGC8617
See related:HGNC:6862|MIM:157132|HPRD:01141
Chromosome:3
Location:3p21
Gene Description:microtubule-associated protein 4
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0939
ORGANISM:human
Entrez Gene ID:4134
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.1 :: -1 :: -1.4 :: -1.5
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
17758CBCerebellum83.1081619262695100.0
17758CTXCerebral cortex61.138221740722757.3067531585693
17758HIPHippocampal region92.610050201416100.0
17758HPFHippocampal formation76.6549873352051100.0
17758HYHypothalamus38.807884216308636.6089553833008
17758LSXLateral septal complex66.87930107116782.2409706115723
17758MBMidbrain66.028320312576.0885620117188
17758MYMedulla54.448781967163176.1869087219238
17758OLFOlfactory bulb58.349021911621167.2875270843506
17758PPons55.112880706787166.8491134643555
17758PALPallidum50.101022720336955.8469543457031
17758RHPRetrohippocampal region53.246515274047953.1865711212158
17758sAMYStriatum-like amygdalar nuclei46.532875061035242.0522441864014
17758STRStriatum29.517013549804727.1006956100464
17758STRdStriatum dorsal region22.697938919067419.9264230728149
17758STRvStriatum ventral region31.151183128356925.8498592376709
17758THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4134GO:0005198TASFunctionstructural molecule activity
4134GO:0005874IEAComponentmicrotubule
4134GO:0005875TASComponentmicrotubule associated complex
4134GO:0007026IEAProcessnegative regulation of microtubule depolymerization
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7280NP_001060.1tubulin, beta 2HPRD01852
NP_002366.17280-Tubulin, betaHPRD01141
NP_002366.157787NP_113605.2MAP/microtubule affinity-regulating kinase 4HPRD09402
NP_002366.157787NP_113605.2MAP/microtubule affinity-regulating kinase 4HPRD01141
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4134IPR013588MAP2_projctnMAP2/Tau projection
4134IPR001084Tau_tubulin_bdTubulin-binding Tau protein
4134MAP4_HUMANP27816IPR013588MAP2_projctnMAP2/Tau projection
4134MAP4_HUMANP27816IPR001084Tau_tubulin_bdTubulin-binding Tau protein

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