Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4137
Official Symbol:MAPT
Other Aliases:DDPAC|FLJ31424|FTDP-17|MAPTL|MGC138549|MSTD|MTBT1|MTBT2|PPND|TAU
See related:HGNC:6893|MIM:157140|HPRD:01142
Chromosome:17
Location:17q21.1
Gene Description:microtubule-associated protein tau
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0290
ORGANISM:human
Entrez Gene ID:4137
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Upregulated
Fold Change:0.77
KARG Evidence 2
KARG ID:EVIM0336
ORGANISM:human
Entrez Gene ID:4137
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Upregulated
Fold Change:0.65
KARG Evidence 3
KARG ID:EVIM1139
ORGANISM:human
Entrez Gene ID:4137
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12716423
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Ventral Tegmental Area
Drug Effects:Downregulated
Fold Change:-
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
17762CBCerebellum100.0100.0
17762CTXCerebral cortex100.0100.0
17762HIPHippocampal region100.0100.0
17762HPFHippocampal formation100.0100.0
17762HYHypothalamus100.0100.0
17762LSXLateral septal complex100.0100.0
17762MBMidbrain100.0100.0
17762MYMedulla100.0100.0
17762OLFOlfactory bulb100.0100.0
17762PPons100.0100.0
17762PALPallidum100.0100.0
17762RHPRetrohippocampal region100.0100.0
17762sAMYStriatum-like amygdalar nuclei100.0100.0
17762STRStriatum100.0100.0
17762STRdStriatum dorsal region100.0100.0
17762STRvStriatum ventral region100.0100.0
17762THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4137GO:0000226IDAProcessmicrotubule cytoskeleton organization and biogenesis
4137GO:0000226ISSProcessmicrotubule cytoskeleton organization and biogenesis
4137GO:0005200ISSFunctionstructural constituent of cytoskeleton
4137GO:0005200TASFunctionstructural constituent of cytoskeleton
4137GO:0005829ISSComponentcytosol
4137GO:0005829TASComponentcytosol
4137GO:0005856IEAComponentcytoskeleton
4137GO:0005875ISSComponentmicrotubule associated complex
4137GO:0005875TASComponentmicrotubule associated complex
4137GO:0005886IDAComponentplasma membrane
4137GO:0005886ISSComponentplasma membrane
4137GO:0007026ISSProcessnegative regulation of microtubule depolymerization
4137GO:0007026NASProcessnegative regulation of microtubule depolymerization
4137GO:0008017IDAFunctionmicrotubule binding
4137GO:0008017ISSFunctionmicrotubule binding
4137GO:0008034IPIFunctionlipoprotein binding
4137GO:0017124IPIFunctionSH3 domain binding
4137GO:0019899IPIFunctionenzyme binding
4137GO:0030424IDAComponentaxon
4137GO:0030424ISSComponentaxon
4137GO:0030424NASComponentaxon
4137GO:0030426IDAComponentgrowth cone
4137GO:0030426ISSComponentgrowth cone
4137GO:0031116IDAProcesspositive regulation of microtubule polymerization
4137GO:0031116ISSProcesspositive regulation of microtubule polymerization
4137GO:0045298IDAComponenttubulin
4137GO:0045298ISSComponenttubulin
4137GO:0045773IDAProcesspositive regulation of axon extension
4137GO:0045773ISSProcesspositive regulation of axon extension
4137GO:0048699ISSProcessneurogenesis
4137GO:0048699NASProcessneurogenesis
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6710NP_000338.2spectrin, beta, erythrocytic (includes spherocytosis, clinical type I)HPRD01686
-7280NP_001060.1tubulin, beta 2HPRD01852
-6812NP_003156.1syntaxin binding protein 1 isoform aHPRD04235
-7529NP_003395.1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptideHPRD03184
-7534NP_003397.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptideHPRD03183
-8473NP_858058.1O-linked GlcNAc transferase isoform 1HPRD02222
NP_058519.1--ActinHPRD01142
NP_058519.1--Beta PPHPRD01142
NP_058519.1--Alpha tubulinHPRD01142
NP_058519.1--Pin1HPRD01142
NP_058519.16285-S100 calcium binding protein, betaHPRD01142
NP_058519.16710-Spectrin, beta IHPRD01142
NP_058519.18473-O-linked N-acetylglucosamine transferaseHPRD01142
NP_058519.17280-Tubulin, betaHPRD01142
NP_058519.17529-14-3-3 BetaHPRD01142
NP_058519.17534-14-3-3 zetaHPRD01142
NP_058519.16285-S100 calcium binding protein, betaHPRD01142
NP_058519.16812-Syntaxin binding protein 1HPRD01142
NP_058519.15663NP_000012.1presenilin 1HPRD01142
NP_058519.16622NP_000336.1alpha-synuclein isoform NACP140HPRD01227
NP_058519.16622NP_000336.1alpha-synuclein isoform NACP140HPRD01142
NP_058519.17534NP_003397.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptideBIND24820
NP_058519.18287NP_004645.1ubiquitin specific protease 9, Y-linkedHPRD02449
NP_058519.18287NP_004645.1ubiquitin specific protease 9, Y-linkedHPRD01142
NP_058519.15300NP_006212.1protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1HPRD03031
NP_058519.15300NP_006212.1protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1HPRD01142
NP_058519.126574NP_036270.1apoptosis antagonizing transcription factorHPRD12236
NP_058519.126574NP_036270.1apoptosis antagonizing transcription factorHPRD01142
NP_058519.157787NP_113605.2MAP/microtubule affinity-regulating kinase 4HPRD09402
NP_058519.157787NP_113605.2MAP/microtubule affinity-regulating kinase 4HPRD01142
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4137IPR013588MAP2_projctnMAP2/Tau projection
4137IPR000694PRO_richProline-rich region
4137IPR002955Tau_proteinTau protein
4137IPR001084Tau_tubulin_bdTubulin-binding Tau protein
4137TAU_HUMANP10636IPR013588MAP2_projctnMAP2/Tau projection
4137TAU_HUMANP10636IPR000694PRO_richProline-rich region
4137TAU_HUMANP10636IPR002955Tau_proteinTau protein
4137TAU_HUMANP10636IPR001084Tau_tubulin_bdTubulin-binding Tau protein

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