Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4155
Official Symbol:MBP
Other Aliases:MGC99675
See related:HGNC:6925|MIM:159430|HPRD:01158
Chromosome:18
Location:18q23
Gene Description:myelin basic protein
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0089
ORGANISM:human
Entrez Gene ID:4155
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:17196
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0070
ORGANISM:human
Entrez Gene ID:4155
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15009677
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-1.38 :: 0.08 :: -0.78 :: -1.45 :: -1.14 :: -1.01 :: -1.30 :: -0.53 :: 0.07 :: -1.94
KARG Evidence 3
KARG ID:EVIM0164
ORGANISM:human
Entrez Gene ID:4155
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:16205370
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:superior frontal gyrus
Drug Effects:Downregulated
Fold Change:-
KARG Evidence 4
KARG ID:EVIM0169
ORGANISM:human
Entrez Gene ID:4155
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:16205370
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-
KARG Evidence 5
KARG ID:EVIM0178
ORGANISM:human
Entrez Gene ID:4155
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15312160
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:-
KARG Evidence 6
KARG ID:EVIM0817
ORGANISM:human
Entrez Gene ID:4155
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.7 :: -1.1
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
17196CBCerebellum100.0100.0
17196CTXCerebral cortex100.0100.0
17196HIPHippocampal region91.9033126831055100.0
17196HPFHippocampal formation97.572146097819100.0
17196HYHypothalamus100.098.2019017537435
17196LSXLateral septal complex100.097.1032943725586
17196MBMidbrain100.0100.0
17196MYMedulla100.0100.0
17196OLFOlfactory bulb100.0100.0
17196PPons100.0100.0
17196PALPallidum100.0100.0
17196RHPRetrohippocampal region100.0100.0
17196sAMYStriatum-like amygdalar nuclei100.099.8788426717122
17196STRStriatum100.0100.0
17196STRdStriatum dorsal region100.0100.0
17196STRvStriatum ventral region97.5832341512044100.0
17196THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4155GO:0006955TASProcessimmune response
4155GO:0007268TASProcesssynaptic transmission
4155GO:0007417TASProcesscentral nervous system development
4155GO:0008366TASProcessnerve ensheathment
4155GO:0019911IEAFunctionstructural constituent of myelin sheath
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-4316NP_002414.1matrix metalloproteinase 7 preproproteinHPRD01525
-9149NP_004705.1dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B isoform aHPRD05188
-6789NP_006273.1serine/threonine kinase 4HPRD05395
-58190NP_067021.1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 isoform 1HPRD05615
-91754NP_149107.3NIMA related kinase 9HPRD11386
-221154NP_689939.1EF hand domain family, member A1HPRD16852
-55589NP_942595.1BMP-2 inducible kinase isoform aHPRD09828
NP_002376.1-P26663Genome polyprotein [Contains: Core protein p21 (Capsid protein C) (p21)BIND193146
NP_002376.16789-STE20 like kinase MST1HPRD01158
NP_002376.14316-Matrix metalloproteinase 7HPRD01158
NP_002376.15580--BIND263430
NP_002376.19149-DYRK1BHPRD01158
NP_002376.155589-BMP-2 inducible protein kinaseHPRD01158
NP_002376.158190-NLI IFHPRD01158
NP_002376.111011AAH44925.1TLK2 proteinHPRD10527
NP_002376.19874BAA20562.1PKU-betaHPRD12232
NP_002376.15354NP_000524.2proteolipid protein 1HPRD02321
NP_002376.15354NP_000524.2proteolipid protein 1HPRD01158
NP_002376.15578NP_002728.1protein kinase C, alphaBIND263431
NP_002376.15584NP_002731.3protein kinase C, iotaBIND263429
NP_002376.15590NP_002735.3protein kinase C, zeta isoform 1BIND263433
NP_002376.15594NP_002736.2mitogen-activated protein kinase 1BIND257753
NP_002376.15603NP_002745.1mitogen-activated protein kinase 13HPRD09113
NP_002376.16732NP_003128.3SFRS protein kinase 1HPRD15992
NP_002376.18569NP_003675.2MAP kinase interacting serine/threonine kinase 1 isoform 1HPRD09468
NP_002376.18569NP_003675.2MAP kinase interacting serine/threonine kinase 1 isoform 1HPRD01158
NP_002376.18576NP_003682.1serine/threonine kinase 16HPRD05281
NP_002376.18576NP_003682.1serine/threonine kinase 16HPRD01158
NP_002376.19475NP_004841.2Rho-associated, coiled-coil containing protein kinase 2BIND258675
NP_002376.16093NP_005397.1Rho-associated, coiled-coil containing protein kinase 1BIND258678
NP_002376.110419NP_006100.2protein arginine methyltransferase 5 isoform aHPRD04955
NP_002376.110419NP_006100.2protein arginine methyltransferase 5 isoform aHPRD01158
NP_002376.127347NP_037365.1serine threonine kinase 39 (STE20/SPS1 homolog, yeast)HPRD09627
NP_002376.127347NP_037365.1serine threonine kinase 39 (STE20/SPS1 homolog, yeast)HPRD01158
NP_002376.151755NP_057591.1CDC2-related protein kinase 7HPRD10849
NP_002376.151765NP_057626.2serine/threonine protein kinase MASKHPRD06663
NP_002376.151765NP_057626.2serine/threonine protein kinase MASKHPRD01158
NP_002376.154822NP_060142.2transient receptor potential cation channel, subfamily M, member 7HPRD10418
NP_002376.1225689NP_620590.1mitogen-activated protein kinase 15HPRD16867
NP_002376.18550NP_620777.1mitogen-activated protein kinase-activated protein kinase 5 isoform 2HPRD09467
NP_002376.18550NP_620777.1mitogen-activated protein kinase-activated protein kinase 5 isoform 2HPRD01158
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4155IPR000548Myelin_BPMyelin basic protein
4155MBP_HUMANP02686IPR000548Myelin_BPMyelin basic protein

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