Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4160
Official Symbol:MC4R
Other Aliases:MGC126851|MGC138197
See related:HGNC:6932|MIM:155541|HPRD:01116
Chromosome:18
Location:18q22
Gene Description:melanocortin 4 receptor
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0593
ORGANISM:human
Entrez Gene ID:4160
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:25635
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
17202CBCerebellum0.4756526648998260.909041523933411
17202CTXCerebral cortex0.4752109199762340.409627616405487
17202HIPHippocampal region0.5776815302670.413311645388603
17202HPFHippocampal formation0.4181923940777780.327583000063896
17202HYHypothalamus0.1910726390779020.18387833610177
17202LSXLateral septal complex1.101481318473821.7732660472393
17202MBMidbrain0.1483368799090390.173486672341824
17202MYMedulla0.2217484042048450.312287881970406
17202OLFOlfactory bulb0.3200458213686940.240098617970943
17202PPons0.7267474383115770.601015888154507
17202PALPallidum0.3399627879261970.343890503048897
17202RHPRetrohippocampal region0.2119579464197160.196167215704918
17202sAMYStriatum-like amygdalar nuclei0.5701474584639070.353069441393018
17202STRStriatum0.4775149822235110.57010392844677
17202STRdStriatum dorsal region0.2739134505391120.306423261761665
17202STRvStriatum ventral region0.1920566037297250.205524079501629
17202THThalamus0.09956304728984830.105082914233208
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4160GO:0001584IEAFunctionrhodopsin-like receptor activity
4160GO:0004872IEAFunctionreceptor activity
4160GO:0004977TASFunctionmelanocortin receptor activity
4160GO:0005886TASComponentplasma membrane
4160GO:0007165IEAProcesssignal transduction
4160GO:0007186IEAProcessG-protein coupled receptor protein signaling pathway
4160GO:0007188TASProcessG-protein signaling, coupled to cAMP nucleotide second messenger
4160GO:0007582TASProcessphysiological process
4160GO:0007631TASProcessfeeding behavior
4160GO:0016021TASComponentintegral to membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-4852NP_000896.1neuropeptide YHPRD01214
-26033NP_997186.1attractin-like 1HPRD12504
NP_005903.1--Agouti-related proteinHPRD01116
NP_005903.14852-Neuropeptide YHPRD01116
NP_005903.15443NP_000930.1proopiomelanocortin preproproteinHPRD01116
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4160MC4R_HUMANP32245IPR002230Cnbnoid_rcptCannabinoid receptor
4160MC4R_HUMANP32245IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
4160MC4R_HUMANP32245IPR000155Mcort_rcpt_4Melanocortin 4 receptor
4160MC4R_HUMANP32245IPR000621Melancort_rcpt_5Melanocortin 5 receptor
4160MC4R_HUMANP32245IPR001908Melancort_rcptMelanocortin receptor
4160MC4R_HUMANP32245IPR001671Melcrt_ACTH_rcptMelanocortin/ACTH receptor
4160MC4R_HUMANP32245IPR000761MSH_rcptMelanocyte-stimulating hormone receptor
4160MC4R_HUMANP32245IPR008365Prostanoid_rcptProstanoid receptor

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