Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4190
Official Symbol:MDH1
Other Aliases:MDH-s|MDHA|MGC:1375|MOR2
See related:HGNC:6970|MIM:154200|HPRD:01100
Chromosome:2
Location:2p13.3
Gene Description:malate dehydrogenase 1, NAD (soluble)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0097
ORGANISM:human
Entrez Gene ID:4190
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:3.20 :: 4.56 :: 6.31 :: 4.38 :: -5.49 :: -3.85 :: -4.10
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
17449CBCerebellum100.0100.0
17449CTXCerebral cortex100.0100.0
17449HIPHippocampal region100.0100.0
17449HPFHippocampal formation100.0100.0
17449HYHypothalamus100.0100.0
17449LSXLateral septal complex100.0100.0
17449MBMidbrain100.0100.0
17449MYMedulla100.0100.0
17449OLFOlfactory bulb100.0100.0
17449PPons100.0100.0
17449PALPallidum100.0100.0
17449RHPRetrohippocampal region100.0100.0
17449sAMYStriatum-like amygdalar nuclei100.0100.0
17449STRStriatum100.0100.0
17449STRdStriatum dorsal region100.0100.0
17449STRvStriatum ventral region100.0100.0
17449THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4190GO:0004459IEAFunctionL-lactate dehydrogenase activity
4190GO:0004470TASFunctionmalic enzyme activity
4190GO:0005829TASComponentcytosol
4190GO:0006096IEAProcessglycolysis
4190GO:0006099IEAProcesstricarboxylic acid cycle
4190GO:0006108IEAProcessmalate metabolism
4190GO:0016491IEAFunctionoxidoreductase activity
4190GO:0030060IEAFunctionL-malate dehydrogenase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_005908.14190NP_005908.1cytosolic malate dehydrogenaseHPRD01100
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4190MDHC_HUMANP40925IPR001236lact_mal_DHLactate/malate dehydrogenase
4190MDHC_HUMANP40925IPR001252MDH_ASMalate dehydrogenase, active site

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