Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4191
Official Symbol:MDH2
Other Aliases:M-MDH|MDH|MGC:3559|MOR1
See related:HGNC:6971|MIM:154100|HPRD:01099
Chromosome:7
Location:7p12.3-q11.2
Gene Description:malate dehydrogenase 2, NAD (mitochondrial)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0480
ORGANISM:human
Entrez Gene ID:4191
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:81829
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
17448CBCerebellum68.5033721923828100.0
17448CTXCerebral cortex100.0100.0
17448HIPHippocampal region100.0100.0
17448HPFHippocampal formation100.0100.0
17448HYHypothalamus100.0100.0
17448LSXLateral septal complex100.0100.0
17448MBMidbrain100.0100.0
17448MYMedulla100.0100.0
17448OLFOlfactory bulb100.0100.0
17448PPons100.0100.0
17448PALPallidum100.0100.0
17448RHPRetrohippocampal region100.0100.0
17448sAMYStriatum-like amygdalar nuclei100.0100.0
17448STRStriatum100.0100.0
17448STRdStriatum dorsal region100.0100.0
17448STRvStriatum ventral region100.0100.0
17448THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4191GO:0000004NDProcessbiological process unknown
4191GO:0004459IEAFunctionL-lactate dehydrogenase activity
4191GO:0005739IEAComponentmitochondrion
4191GO:0005759NASComponentmitochondrial matrix
4191GO:0006096IEAProcessglycolysis
4191GO:0006099IEAProcesstricarboxylic acid cycle
4191GO:0006108IEAProcessmalate metabolism
4191GO:0016491IEAFunctionoxidoreductase activity
4191GO:0030060NASFunctionL-malate dehydrogenase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5091NP_000911.1pyruvate carboxylase precursorHPRD02032
-4719NP_004997.1NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)HPRD01145
NP_005909.24719-NADH ubiquinone oxidoreductase Fe-S protein 1HPRD01099
NP_005909.25091-Pyruvate carboxylaseHPRD01099
NP_005909.24191NP_005909.2mitochondrial malate dehydrogenase precursorHPRD01099
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4191MDHM_HUMANP40926IPR001236lact_mal_DHLactate/malate dehydrogenase
4191MDHM_HUMANP40926IPR001252MDH_ASMalate dehydrogenase, active site

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