Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4192
Official Symbol:MDK
Other Aliases:FLJ27379|MK|NEGF2
See related:HGNC:6972|MIM:162096|HPRD:01200
Chromosome:11
Location:11p11.2
Gene Description:midkine (neurite growth-promoting factor 2)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0294
ORGANISM:human
Entrez Gene ID:4192
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Upregulated
Fold Change:0.96
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
17242CBCerebellum32.902157783508329.2423152923584
17242CTXCerebral cortex6.985981464385994.5376992225647
17242HIPHippocampal region10.69035959243775.69546937942505
17242HPFHippocampal formation10.87631130218517.03067779541016
17242HYHypothalamus3.281944453716282.25119137763977
17242LSXLateral septal complex4.627113580703744.97383379936218
17242MBMidbrain3.642722010612494.39803779125214
17242MYMedulla7.722393989562996.49205994606018
17242OLFOlfactory bulb15.81668806076058.75904035568237
17242PPons5.492902040481574.99237060546875
17242PALPallidum0.8926228284835820.722227722406387
17242RHPRetrohippocampal region10.99383449554448.50749635696411
17242sAMYStriatum-like amygdalar nuclei4.629703998565673.09075605869293
17242STRStriatum3.707957386970523.31981956958771
17242STRdStriatum dorsal region2.373279809951782.60878551006317
17242STRvStriatum ventral region5.037236452102662.98375654220581
17242THThalamus3.549321293830872.45215487480164
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4192GO:0000074IEAProcessregulation of progression through cell cycle
4192GO:0005125NRFunctioncytokine activity
4192GO:0005615NRComponentextracellular space
4192GO:0007165NASProcesssignal transduction
4192GO:0007267NRProcesscell-cell signaling
4192GO:0007399NASProcessnervous system development
4192GO:0008083NASFunctiongrowth factor activity
4192GO:0008201IDAFunctionheparin binding
4192GO:0008283IEAProcesscell proliferation
4192GO:0009611ISSProcessresponse to wounding
4192GO:0030154NASProcesscell differentiation
4192GO:0030325ISSProcessadrenal gland development
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7051NP_000350.1transglutaminase 1HPRD01824
-6382NP_002988.3syndecan 1 precursorHPRD01718
-6385NP_002990.2syndecan 4 precursorHPRD08366
-6772NP_009330.1signal transducer and activator of transcription 1 isoform alphaHPRD02777
-9672NP_055469.1syndecan 3HPRD01719
NP_001012333.1---BIND315962
NP_002382.16385-Syndecan 4HPRD01200
NP_002382.16382-Syndecan 1HPRD01200
NP_002382.19672-Syndecan 3HPRD01200
NP_002382.17051-Transglutaminase 1HPRD01200
NP_002382.16772-STAT1HPRD01200
NP_002382.15803-Protein tyrosine phosphatase, receptor zeta 1HPRD01200
NP_002382.15787-Receptor type protein tyrosine phosphatase betaHPRD01200
NP_002382.14691NP_005372.1nucleolinHPRD01245
NP_002382.14691NP_005372.1nucleolinHPRD01200
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4192MK_HUMANP21741IPR000762PTN_MK_hepar_bdPTN/MK heparin-binding protein

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