Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4208
Official Symbol:MEF2C
Other Aliases:-
See related:HGNC:6996|MIM:600662|HPRD:02809
Chromosome:5
Location:5q14
Gene Description:MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0203
ORGANISM:human
Entrez Gene ID:4208
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:17260
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
17260CBCerebellum17.21856844425234.9169575572014
17260CTXCerebral cortex100.0100.0
17260HIPHippocampal region62.715306758880673.2590780258179
17260HPFHippocampal formation75.363310813903886.1632871627808
17260HYHypothalamus11.04386276006710.5214982181787
17260LSXLateral septal complex43.531089782714843.3428301811218
17260MBMidbrain20.042227745056222.1323467493057
17260MYMedulla16.533093109726919.6895876005292
17260OLFOlfactory bulb100.0100.0
17260PPons12.578074783086814.3136608600616
17260PALPallidum26.607989072799730.9925940036774
17260RHPRetrohippocampal region91.628099441528399.9711952209473
17260sAMYStriatum-like amygdalar nuclei51.248474121093859.6278772354126
17260STRStriatum59.772068500518860.0290195941925
17260STRdStriatum dorsal region57.882476091384957.2071844339371
17260STRvStriatum ventral region73.057852745056268.5559577941895
17260THThalamus47.301288247108549.8871203660965
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4208GO:0003700NASFunctiontranscription factor activity
4208GO:0003702TASFunctionRNA polymerase II transcription factor activity
4208GO:0003713NRFunctiontranscription coactivator activity
4208GO:0005634IEAComponentnucleus
4208GO:0006350IEAProcesstranscription
4208GO:0006355IEAProcessregulation of transcription, DNA-dependent
4208GO:0006366NRProcesstranscription from RNA polymerase II promoter
4208GO:0007399TASProcessnervous system development
4208GO:0007517TASProcessmuscle development
4208GO:0043565IEAFunctionsequence-specific DNA binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-4209NP_005911.1MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)HPRD02810
-9759NP_006028.1histone deacetylase 4HPRD05610
-54345NP_060889.1SRY-box 18HPRD07208
-117581NP_476527.1twist homolog 2HPRD09616
-6667NP_612482.2Sp1 transcription factorHPRD01796
-5598NP_620603.1mitogen-activated protein kinase 7 isoform 1HPRD03952
NP_002388.2--GATA-4HPRD02809
NP_002388.26667-Transcription factor Sp1HPRD02809
NP_002388.25598-ERK5HPRD02809
NP_002388.24209-Myocyte specific enhancer factor 2DHPRD02809
NP_002388.29759-Histone deacetylase 4HPRD02809
NP_002388.254345-SRY box 18HPRD02809
NP_002388.2117581-Dermis expressed protein 1HPRD02809
NP_002388.25598--BIND215378
NP_002388.29686NP_055482.1vestigial like 4HPRD11672
NP_002388.254345NP_060889.1SRY-box 18BIND13103
NP_002388.2245806NP_703154.1vestigial-like 2 isoform 2HPRD18282
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4208MEF2C_HUMANQ06413IPR002100TF_MADSboxTranscription factor, MADS-box

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