Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4256
Official Symbol:MGP
Other Aliases:GIG36|MGLAP|NTI
See related:HGNC:7060|MIM:154870|HPRD:01112
Chromosome:12
Location:12p13.1-p12.3
Gene Description:matrix Gla protein
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0217
ORGANISM:human
Entrez Gene ID:4256
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Downregulated
Fold Change:At least 2-folds difference
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
17313CBCerebellum7.7044242620468112.4005298614502
17313CTXCerebral cortex2.625797331333163.26009571552277
17313HIPHippocampal region4.157777309417724.90705013275146
17313HPFHippocampal formation3.948127150535584.6939070224762
17313HYHypothalamus2.697263777256013.60380303859711
17313LSXLateral septal complex2.943832993507397.99229574203491
17313MBMidbrain5.403715848922739.69416904449463
17313MYMedulla7.3279865980148312.0927872657776
17313OLFOlfactory bulb5.023553967475894.94689345359802
17313PPons7.1931343078613312.3360195159912
17313PALPallidum1.86216717958453.29726535081863
17313RHPRetrohippocampal region3.232646167278294.15858519077301
17313sAMYStriatum-like amygdalar nuclei3.927439153194438.35566735267639
17313STRStriatum1.987027525901793.5285542011261
17313STRdStriatum dorsal region1.427799224853522.2839822769165
17313STRvStriatum ventral region1.809564113616941.85048773884773
17313THThalamus2.784247756004334.28988075256348
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4256GO:0001502TASProcesscartilage condensation
4256GO:0001503TASProcessossification
4256GO:0005201TASFunctionextracellular matrix structural constituent
4256GO:0005509IEAFunctioncalcium ion binding
4256GO:0005578TASComponentextracellular matrix (sensu Metazoa)
4256GO:0007605IEAProcesssensory perception of sound
4256GO:0008147TASFunctionstructural constituent of bone
4256GO:0030154IEAProcesscell differentiation
4256GO:0030500IEAProcessregulation of bone mineralization
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
AAH05272.1-CAB46677.1polyproteinBIND195936
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4256MGP_HUMANP08493IPR002384GLA_boneBone matrix, Gla region
4256MGP_HUMANP08493IPR000294VitK_dep_GLAVitamin K-dependent carboxylation/gamma-carboxyglutamic region

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