Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:427
Official Symbol:ASAH1
Other Aliases:AC|ASAH|FLJ21558|FLJ22079|PHP|PHP32
See related:HGNC:735|MIM:228000|HPRD:01969
Chromosome:8
Location:8p22-p21.3
Gene Description:N-acylsphingosine amidohydrolase (acid ceramidase) 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0009
ORGANISM:human
Entrez Gene ID:427
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:11886
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11886CBCerebellum35.607391357421984.4392471313477
11886CTXCerebral cortex100.0100.0
11886HIPHippocampal region98.9923629760742100.0
11886HPFHippocampal formation100.0100.0
11886HYHypothalamus81.113311767578187.6167068481445
11886LSXLateral septal complex81.684974670410278.1615219116211
11886MBMidbrain81.47888946533296.5726013183594
11886MYMedulla81.3041076660156100.0
11886OLFOlfactory bulb90.6443099975586100.0
11886PPons68.816932678222791.8882827758789
11886PALPallidum68.256912231445382.5874252319336
11886RHPRetrohippocampal region100.0100.0
11886sAMYStriatum-like amygdalar nuclei76.097137451171974.7658538818359
11886STRStriatum80.767425537109475.5454330444336
11886STRdStriatum dorsal region76.439926147460969.9694747924805
11886STRvStriatum ventral region100.095.7962799072266
11886THThalamus100.0100.0
KARG Evidence 2
KARG ID:HOT0094
Entrez Gene ID:427
RefSeq ID:NM_177924
Position Information:-, Enhancer, 81486bp
Linkage Marker:AFM333TH1
Evidence Type:LINKAGE-BASED (SINGLE POINT)
Evidence Name:PUBMED
Evidence ID:9603606
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
427GO:0005764IEAComponentlysosome
427GO:0006631NRProcessfatty acid metabolism
427GO:0006672TASProcessceramide metabolism
427GO:0016787IEAFunctionhydrolase activity
427GO:0017040IEAFunctionceramidase activity
427GO:0019752IEAProcesscarboxylic acid metabolism
427GO:0046912IEAFunctiontransferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
427IPR003199Chlgly_hydrolaseCholoylglycine hydrolase
427ASAH1_HUMANQ13510IPR003199Chlgly_hydrolaseCholoylglycine hydrolase
427ASAH1_HUMANQ13510IPR008107Mycoplasma_p48Mycoplasma P48 major surface lipoprotein

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