Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4311
Official Symbol:MME
Other Aliases:CALLA|CD10|DKFZp686O16152|MGC126681|MGC126707|NEP
See related:HGNC:7154|MIM:120520|HPRD:00392
Chromosome:3
Location:3q25.1-q25.2
Gene Description:membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIL0052
ORGANISM:human
Entrez Gene ID:4311
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:10994648
Addiction Drug:POLYSUBSTANCE
Addiction Drug Detail:DRUG ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
17380CBCerebellum7.161988735198977.90254831314087
17380CTXCerebral cortex4.641699790954593.71883749961853
17380HIPHippocampal region5.358170986175546.31519174575806
17380HPFHippocampal formation6.319233417510996.44008159637451
17380HYHypothalamus6.515534400939945.72283983230591
17380LSXLateral septal complex0.3789228796958920.271979957818985
17380MBMidbrain4.323338985443124.00263690948486
17380MYMedulla9.513731002807629.95315837860107
17380OLFOlfactory bulb3.974403858184813.93633818626404
17380PPons6.367557525634776.43466234207153
17380PALPallidum10.662983894348111.1631374359131
17380RHPRetrohippocampal region8.281708717346196.96334409713745
17380sAMYStriatum-like amygdalar nuclei1.532294034957891.47661411762238
17380STRStriatum23.789440155029320.8017616271973
17380STRdStriatum dorsal region34.844837188720730.9014644622803
17380STRvStriatum ventral region9.542685508728038.20261669158936
17380THThalamus4.724432468414314.65290594100952
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4311GO:0004245IEAFunctionneprilysin activity
4311GO:0005886TASComponentplasma membrane
4311GO:0005887TASComponentintegral to plasma membrane
4311GO:0006508TASProcessproteolysis
4311GO:0007267TASProcesscell-cell signaling
4311GO:0008237TASFunctionmetallopeptidase activity
4311GO:0008270IEAFunctionzinc ion binding
4311GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5291NP_006210.1phosphoinositide-3-kinase, catalytic, beta polypeptideHPRD04234
-6464NP_892113.1SHC (Src homology 2 domain containing) transforming protein 1HPRD02780
NP_000893.16464-SHCHPRD00392
NP_000893.15291-Phosphatidylinositol 3-kinase, catalytic betaHPRD00392
NP_000893.15295-Phosphatidylinositol 3 kinase regulatory subunit, alphaHPRD00392
NP_000893.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4311NEP_HUMANP08473IPR000718Peptidase_M13Peptidase M13, neprilysin
4311NEP_HUMANP08473IPR008753Peptidase_M13_NPeptidase M13
4311NEP_HUMANP08473IPR006025Pept_M_Zn_BSPeptidase M, neutral zinc metallopeptidases, zinc-binding site

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