Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4359
Official Symbol:MPZ
Other Aliases:CHM|CMT1|CMT1B|CMT2I|CMT2J|CMT4E|CMTDI3|DSS|HMSNIB|MPP|P0
See related:HGNC:7225|MIM:159440|HPRD:01159
Chromosome:1
Location:1q22
Gene Description:myelin protein zero (Charcot-Marie-Tooth neuropathy 1B)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0820
ORGANISM:human
Entrez Gene ID:4359
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.2 :: -1.1 :: -1.2 :: -1.7
KARG Evidence 2
KARG ID:EVIM0821
ORGANISM:human
Entrez Gene ID:4359
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.1 :: 2.4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
17528CBCerebellum12.232451438903817.0146522521973
17528CTXCerebral cortex14.765789031982411.0796756744385
17528HIPHippocampal region5.229392051696784.73232507705688
17528HPFHippocampal formation8.028501510620127.13420581817627
17528HYHypothalamus1.122637629508971.07264494895935
17528LSXLateral septal complex0.9915906786918640.707387983798981
17528MBMidbrain2.591832399368292.87907862663269
17528MYMedulla11.695661544799812.9401693344116
17528OLFOlfactory bulb11.800402641296410.2964315414429
17528PPons6.587513446807867.72861194610596
17528PALPallidum1.917665362358091.5569384098053
17528RHPRetrohippocampal region13.201044082641610.9432163238525
17528sAMYStriatum-like amygdalar nuclei1.781030535697941.43804574012756
17528STRStriatum2.491617918014531.87737345695496
17528STRdStriatum dorsal region2.482601404190061.89445006847382
17528STRvStriatum ventral region3.410507202148442.35764193534851
17528THThalamus1.836138963699341.61833596229553
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4359GO:0005198IEAFunctionstructural molecule activity
4359GO:0005198NASFunctionstructural molecule activity
4359GO:0005554NDFunctionmolecular function unknown
4359GO:0005886NASComponentplasma membrane
4359GO:0005887TASComponentintegral to plasma membrane
4359GO:0007156NRProcesshomophilic cell adhesion
4359GO:0007268TASProcesssynaptic transmission
4359GO:0007422NRProcessperipheral nervous system development
4359GO:0007638IEAProcessmechanosensory behavior
4359GO:0008366NASProcessnerve ensheathment
4359GO:0008372NDComponentcellular component unknown
4359GO:0016020IEAComponentmembrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5376NP_000295.1peripheral myelin protein 22HPRD03059
NP_000521.15376-Peripheral myelin protein 22HPRD01159
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4359MYP0_HUMANP25189IPR007110Ig-likeImmunoglobulin-like
4359MYP0_HUMANP25189IPR000920Myelin_P0Myelin P0 protein
4359MYP0_HUMANP25189IPR013106V-setImmunoglobulin V-set

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