Knowledgebase for Addiction-Related Genes
Home | Score | Chromosome | Pathway | Advanced Search | BLAST Search | Downloads | Publications | FAQ & Help |   

KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4485
Official Symbol:MST1
Other Aliases:D3F15S2|DNF15S2|HGFL|MSP|NF15S2
See related:HGNC:7380|MIM:142408|HPRD:00798
Chromosome:3
Location:3p21
Gene Description:macrophage stimulating 1 (hepatocyte growth factor-like)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0420
ORGANISM:human
Entrez Gene ID:4485
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.3 :: -1.2 :: -1.4 :: -1.1
KARG Evidence 2
KARG ID:EVIM0488
ORGANISM:human
Entrez Gene ID:4485
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1.1 :: -1.1 :: -1.6 :: -1.5 :: -1.4
KARG Evidence 3
KARG ID:EVIM0880
ORGANISM:human
Entrez Gene ID:4485
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-3 :: -1.8
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
15235CBCerebellum1.508168578147892.24098324775696
15235CTXCerebral cortex1.71659612655641.51128566265106
15235HIPHippocampal region0.9429240822792050.733669698238373
15235HPFHippocampal formation0.7645255327224730.59735506772995
15235HYHypothalamus0.5636992454528810.427896827459335
15235LSXLateral septal complex0.3284272849559780.311608046293259
15235MBMidbrain1.051473021507260.912748217582703
15235MYMedulla1.460289001464841.04522430896759
15235OLFOlfactory bulb3.655699729919434.27223539352417
15235PPons0.9970875978469850.710041224956512
15235PALPallidum1.528275370597841.82508254051208
15235RHPRetrohippocampal region0.4886192977428440.437945872545242
15235sAMYStriatum-like amygdalar nuclei0.1841109693050380.0815401300787926
15235STRStriatum0.42650568485260.348121553659439
15235STRdStriatum dorsal region0.3740909099578860.37736377120018
15235STRvStriatum ventral region0.6392070651054380.302346795797348
15235THThalamus3.523141860961915.42017078399658
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4485GO:0000004NDProcessbiological process unknown
4485GO:0004252IEAFunctionserine-type endopeptidase activity
4485GO:0005509IEAFunctioncalcium ion binding
4485GO:0005554NDFunctionmolecular function unknown
4485GO:0006508IEAProcessproteolysis
4485GO:0007596IEAProcessblood coagulation
4485GO:0008372NDComponentcellular component unknown
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_066278.24486NP_002438.1macrophage stimulating 1 receptorHPRD02545
NP_066278.24486NP_002438.1macrophage stimulating 1 receptorHPRD00798
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4485HGFL_HUMANP26927IPR000001KringleKringle
4485HGFL_HUMANP26927IPR003014PANN/apple PAN
4485HGFL_HUMANP26927IPR001254Peptidase_S1_S6Peptidase S1 and S6, chymotrypsin/Hap
4485HGFL_HUMANP26927IPR001314Peptidase_S1APeptidase S1A, chymotrypsin
4485HGFL_HUMANP26927IPR003966Peptidase_S1A_ppPeptidase S1A, prothrombin/plasminogen

© Center for Bioinformatics(CBI), Peking University
Any Comments and suggestions to : KARG GROUP.