Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4719
Official Symbol:NDUFS1
Other Aliases:CI-75Kd|MGC26839|PRO1304
See related:HGNC:7707|MIM:157655|HPRD:01145
Chromosome:2
Location:2q33-q34
Gene Description:NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0012
ORGANISM:human
Entrez Gene ID:4719
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:227197
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0268
ORGANISM:human
Entrez Gene ID:4719
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Downregulated
Fold Change:-0.56
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
227197CBCerebellum42.032466888427735.7123966217041
227197CTXCerebral cortex43.442480564117425.3568835258484
227197HIPHippocampal region52.96499156951938.8333513736725
227197HPFHippocampal formation58.694284439086946.2619686126709
227197HYHypothalamus39.413456201553322.2235285043716
227197LSXLateral septal complex21.64275145530710.9634364396334
227197MBMidbrain57.220182418823244.3038892745972
227197MYMedulla58.961358070373553.3357057571411
227197OLFOlfactory bulb55.985386371612531.0198681354523
227197PPons60.581569671630958.0299692153931
227197PALPallidum29.710655927658124.0821387767792
227197RHPRetrohippocampal region59.140568733215354.4979653358459
227197sAMYStriatum-like amygdalar nuclei27.063436508178714.2827277779579
227197STRStriatum19.66467398405089.93713822960854
227197STRdStriatum dorsal region11.1459571719175.95690384507179
227197STRvStriatum ventral region43.639634490013119.133172929287
227197THThalamus42.08751678466826.3506927490234
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4719GO:0003954IEAFunctionNADH dehydrogenase activity
4719GO:0005506IEAFunctioniron ion binding
4719GO:0005624NRComponentmembrane fraction
4719GO:0005739IEAComponentmitochondrion
4719GO:0006118IEAProcesselectron transport
4719GO:0006120TASProcessmitochondrial electron transport, NADH to ubiquinone
4719GO:0008137TASFunctionNADH dehydrogenase (ubiquinone) activity
4719GO:0046872IEAFunctionmetal ion binding
4719GO:0051537IEAFunction2 iron, 2 sulfur cluster binding
4719GO:0051539IEAFunction4 iron, 4 sulfur cluster binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4719NUAM_HUMANP28331IPR000283Complex1_75KRespiratory-chain NADH dehydrogenase 75 kDa subunit
4719NUAM_HUMANP28331IPR001041FerredoxinFerredoxin
4719NUAM_HUMANP28331IPR006656MolybdopterinMolybdopterin oxidoreductase

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