Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4724
Official Symbol:NDUFS4
Other Aliases:AQDQ
See related:HGNC:7711|MIM:602694|HPRD:04073
Chromosome:5
Location:5q11.1
Gene Description:NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0277
ORGANISM:human
Entrez Gene ID:4724
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Downregulated
Fold Change:-1.84
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
17993CBCerebellum18.173057556152361.4410018920898
17993CTXCerebral cortex100.0100.0
17993HIPHippocampal region94.7474670410156100.0
17993HPFHippocampal formation91.2356719970703100.0
17993HYHypothalamus37.439987182617243.0471382141113
17993LSXLateral septal complex19.355039596557617.9206008911133
17993MBMidbrain36.000144958496148.4807968139648
17993MYMedulla28.534872055053754.7749900817871
17993OLFOlfactory bulb70.589164733886783.9023818969727
17993PPons34.96135330200258.3934669494629
17993PALPallidum38.005481719970748.0942573547363
17993RHPRetrohippocampal region84.366546630859497.2025299072266
17993sAMYStriatum-like amygdalar nuclei40.82733535766640.0013771057129
17993STRStriatum75.552307128906273.3070526123047
17993STRdStriatum dorsal region87.58214569091885.8451156616211
17993STRvStriatum ventral region74.835327148437569.928466796875
17993THThalamus77.6837615966797100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4724GO:0003954IEAFunctionNADH dehydrogenase activity
4724GO:0005624TASComponentmembrane fraction
4724GO:0005739IEAComponentmitochondrion
4724GO:0006118IEAProcesselectron transport
4724GO:0006120TASProcessmitochondrial electron transport, NADH to ubiquinone
4724GO:0008137TASFunctionNADH dehydrogenase (ubiquinone) activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4724NUYM_HUMANO43181IPR006885ETC_CI_21ETC complex I subunit conserved region

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