Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4741
Official Symbol:NEF3
Other Aliases:NEFM|NF-M|NFM
See related:HGNC:7734|MIM:162250|HPRD:01205
Chromosome:8
Location:8p21
Gene Description:neurofilament 3 (150kDa medium)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0105
ORGANISM:human
Entrez Gene ID:4741
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:2.06 :: 2.14 :: 1.83 :: 2.50 :: -1.52 :: -0.89 :: -2.29
KARG Evidence 2
KARG ID:EVIM0219
ORGANISM:human
Entrez Gene ID:4741
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Upregulated
Fold Change:At least 2-folds difference
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18040CBCerebellum52.0807819366455100.0
18040CTXCerebral cortex100.0100.0
18040HIPHippocampal region96.3902130126953100.0
18040HPFHippocampal formation95.2484016418457100.0
18040HYHypothalamus70.7939834594727100.0
18040LSXLateral septal complex64.985153198242282.4694862365723
18040MBMidbrain97.0323600769043100.0
18040MYMedulla95.3721809387207100.0
18040OLFOlfactory bulb89.3964080810547100.0
18040PPons99.0477485656738100.0
18040PALPallidum83.3078804016113100.0
18040RHPRetrohippocampal region88.417537689209100.0
18040sAMYStriatum-like amygdalar nuclei72.439041137695399.9053001403809
18040STRStriatum100.0100.0
18040STRdStriatum dorsal region100.0100.0
18040STRvStriatum ventral region100.0100.0
18040THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4741GO:0005200TASFunctionstructural constituent of cytoskeleton
4741GO:0005883TASComponentneurofilament
4741GO:0030424TASComponentaxon
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6812NP_003156.1syntaxin binding protein 1 isoform aHPRD04235
NP_005373.1--ApoE3HPRD01205
NP_005373.16812-Syntaxin binding protein 1HPRD01205
NP_005373.14744NP_066554.1neurofilament, heavy polypeptide (200kD)HPRD01204
NP_005373.14744NP_066554.1neurofilament, heavy polypeptide (200kD)HPRD01205
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4741NFM_HUMANP07197IPR006821filament_DNA_bdIntermediate filament, DNA-binding region
4741NFM_HUMANP07197IPR001664IFIntermediate filament protein
4741NFM_HUMANP07197IPR002957Keratin_IKeratin, type I
4741NFM_HUMANP07197IPR003054Keratin_IIType II keratin
4741NFM_HUMANP07197IPR000533TropomyosinTropomyosin

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