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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry

For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information Gene ID: 4741 Official Symbol: NEF3 Other Aliases: NEFM|NF-M|NFM See related: HGNC:7734|MIM:162250|HPRD:01205 Chromosome: 8 Location: 8p21 Gene Description: neurofilament 3 (150kDa medium) Gene type: protein-coding Gene Structure: Genomic Context: KARG Evidence 1 KARG ID: EVIM0105 ORGANISM: human Entrez Gene ID: 4741 Evidence Type: Microarray Evidence ID Type: PUBMED Evidence ID: 12629581 Addiction Drug: COCAINE Addiction Drug Detail: COCAINE ABUSE Addiction Brain Area: Dorsolateral Prefrontal Cortex Drug Effects: Upregulated/Downregulated Fold Change: 2.06 :: 2.14 :: 1.83 :: 2.50 :: -1.52 :: -0.89 :: -2.29 KARG Evidence 2 KARG ID: EVIM0219 ORGANISM: human Entrez Gene ID: 4741 Evidence Type: Microarray Evidence ID Type: PUBMED Evidence ID: 11093800 Addiction Drug: ALCOHOL Addiction Drug Detail: ALCOHOL ADMINISTRATION Addiction Brain Area: SH-SY5Y neuroblastoma cells Drug Effects: Upregulated Fold Change: At least 2-folds difference Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas) Mouse Entrez Gene ID Brain Region Brain Region Detail Expression Level Expression Density 18040 CB Cerebellum 52.0807819366455 100.0 18040 CTX Cerebral cortex 100.0 100.0 18040 HIP Hippocampal region 96.3902130126953 100.0 18040 HPF Hippocampal formation 95.2484016418457 100.0 18040 HY Hypothalamus 70.7939834594727 100.0 18040 LSX Lateral septal complex 64.9851531982422 82.4694862365723 18040 MB Midbrain 97.0323600769043 100.0 18040 MY Medulla 95.3721809387207 100.0 18040 OLF Olfactory bulb 89.3964080810547 100.0 18040 P Pons 99.0477485656738 100.0 18040 PAL Pallidum 83.3078804016113 100.0 18040 RHP Retrohippocampal region 88.417537689209 100.0 18040 sAMY Striatum-like amygdalar nuclei 72.4390411376953 99.9053001403809 18040 STR Striatum 100.0 100.0 18040 STRd Striatum dorsal region 100.0 100.0 18040 STRv Striatum ventral region 100.0 100.0 18040 TH Thalamus 100.0 100.0 Gene Ontology Gene ID GO ID Evidence GO Type GO Description 4741 GO:0005200 TAS Function structural constituent of cytoskeleton 4741 GO:0005883 TAS Component neurofilament 4741 GO:0030424 TAS Component axon Interaction Information Gene Product ID Interactant Gene ID Interactant Gene Product ID Interactant Gene Product Name Source Source ID - 6812 NP_003156.1 syntaxin binding protein 1 isoform a HPRD 04235 NP_005373.1 - - ApoE3 HPRD 01205 NP_005373.1 6812 - Syntaxin binding protein 1 HPRD 01205 NP_005373.1 4744 NP_066554.1 neurofilament, heavy polypeptide (200kD) HPRD 01204 NP_005373.1 4744 NP_066554.1 neurofilament, heavy polypeptide (200kD) HPRD 01205 Domain Information Gene ID Uniprot/Swissprot ID Uniprot/Swissprot ACC Interpro ID Interpro Short Description Interpro Long Description 4741 NFM_HUMAN P07197 IPR006821 filament_DNA_bd Intermediate filament, DNA-binding region 4741 NFM_HUMAN P07197 IPR001664 IF Intermediate filament protein 4741 NFM_HUMAN P07197 IPR002957 Keratin_I Keratin, type I 4741 NFM_HUMAN P07197 IPR003054 Keratin_II Type II keratin 4741 NFM_HUMAN P07197 IPR000533 Tropomyosin Tropomyosin © Center for Bioinformatics(CBI), Peking University Any Comments and suggestions to : KARG GROUP.