Basic Information | Gene ID: | 4741 | Official Symbol: | NEF3 | Other Aliases: | NEFM|NF-M|NFM | See related: | HGNC:7734|MIM:162250|HPRD:01205 | Chromosome: | 8 | Location: | 8p21 | Gene Description: | neurofilament 3 (150kDa medium) | Gene type: | protein-coding | Gene Structure: |  | Genomic Context: |  |
KARG Evidence 1 | KARG ID: | EVIM0105 | ORGANISM: | human | Entrez Gene ID: | 4741 | Evidence Type: | Microarray | Evidence ID Type: | PUBMED | Evidence ID: | 12629581 | Addiction Drug: | COCAINE | Addiction Drug Detail: | COCAINE ABUSE | Addiction Brain Area: | Dorsolateral Prefrontal Cortex | Drug Effects: | Upregulated/Downregulated | Fold Change: | 2.06 :: 2.14 :: 1.83 :: 2.50 :: -1.52 :: -0.89 :: -2.29 |
KARG Evidence 2 | KARG ID: | EVIM0219 | ORGANISM: | human | Entrez Gene ID: | 4741 | Evidence Type: | Microarray | Evidence ID Type: | PUBMED | Evidence ID: | 11093800 | Addiction Drug: | ALCOHOL | Addiction Drug Detail: | ALCOHOL ADMINISTRATION | Addiction Brain Area: | SH-SY5Y neuroblastoma cells | Drug Effects: | Upregulated | Fold Change: | At least 2-folds difference |
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas) | Mouse Entrez Gene ID | Brain Region | Brain Region Detail | Expression Level | Expression Density | 18040 | CB | Cerebellum | 52.0807819366455 | 100.0 | 18040 | CTX | Cerebral cortex | 100.0 | 100.0 | 18040 | HIP | Hippocampal region | 96.3902130126953 | 100.0 | 18040 | HPF | Hippocampal formation | 95.2484016418457 | 100.0 | 18040 | HY | Hypothalamus | 70.7939834594727 | 100.0 | 18040 | LSX | Lateral septal complex | 64.9851531982422 | 82.4694862365723 | 18040 | MB | Midbrain | 97.0323600769043 | 100.0 | 18040 | MY | Medulla | 95.3721809387207 | 100.0 | 18040 | OLF | Olfactory bulb | 89.3964080810547 | 100.0 | 18040 | P | Pons | 99.0477485656738 | 100.0 | 18040 | PAL | Pallidum | 83.3078804016113 | 100.0 | 18040 | RHP | Retrohippocampal region | 88.417537689209 | 100.0 | 18040 | sAMY | Striatum-like amygdalar nuclei | 72.4390411376953 | 99.9053001403809 | 18040 | STR | Striatum | 100.0 | 100.0 | 18040 | STRd | Striatum dorsal region | 100.0 | 100.0 | 18040 | STRv | Striatum ventral region | 100.0 | 100.0 | 18040 | TH | Thalamus | 100.0 | 100.0 |
Gene Ontology | Gene ID | GO ID | Evidence | GO Type | GO Description | 4741 | GO:0005200 | TAS | Function | structural constituent of cytoskeleton | 4741 | GO:0005883 | TAS | Component | neurofilament | 4741 | GO:0030424 | TAS | Component | axon |
Interaction Information | Gene Product ID | Interactant Gene ID | Interactant Gene Product ID | Interactant Gene Product Name | Source | Source ID | - | 6812 | NP_003156.1 | syntaxin binding protein 1 isoform a | HPRD | 04235 | NP_005373.1 | - | - | ApoE3 | HPRD | 01205 | NP_005373.1 | 6812 | - | Syntaxin binding protein 1 | HPRD | 01205 | NP_005373.1 | 4744 | NP_066554.1 | neurofilament, heavy polypeptide (200kD) | HPRD | 01204 | NP_005373.1 | 4744 | NP_066554.1 | neurofilament, heavy polypeptide (200kD) | HPRD | 01205 |
Domain Information | Gene ID | Uniprot/Swissprot ID | Uniprot/Swissprot ACC | Interpro ID | Interpro Short Description | Interpro Long Description | 4741 | NFM_HUMAN | P07197 | IPR006821 | filament_DNA_bd | Intermediate filament, DNA-binding region | 4741 | NFM_HUMAN | P07197 | IPR001664 | IF | Intermediate filament protein | 4741 | NFM_HUMAN | P07197 | IPR002957 | Keratin_I | Keratin, type I | 4741 | NFM_HUMAN | P07197 | IPR003054 | Keratin_II | Type II keratin | 4741 | NFM_HUMAN | P07197 | IPR000533 | Tropomyosin | Tropomyosin |
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