Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4744
Official Symbol:NEFH
Other Aliases:NFH
See related:HGNC:7737|MIM:162230|HPRD:01204
Chromosome:22
Location:22q12.2
Gene Description:neurofilament, heavy polypeptide 200kDa
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIL0120
ORGANISM:human
Entrez Gene ID:4744
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:15236863
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0362
ORGANISM:human
Entrez Gene ID:4744
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:-1.1 :: 1.1 :: 1.4 :: 2.3 :: -1.1.1.8
KARG Evidence 3
KARG ID:EVIM0430
ORGANISM:human
Entrez Gene ID:4744
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:1.4 :: 1.4 :: -1.4 :: -1.1 :: -1.1
KARG Evidence 4
KARG ID:QTL0173
ORGANISM:human
Entrez Gene ID:4744
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
380684CBCerebellum38.0373649597168100.0
380684CTXCerebral cortex58.608366012573271.8078689575195
380684HIPHippocampal region36.922262191772566.0648555755615
380684HPFHippocampal formation45.893875122070367.9210109710693
380684HYHypothalamus51.183282852172965.9714431762695
380684LSXLateral septal complex54.044404983520552.7144165039062
380684MBMidbrain72.0832138061523100.0
380684MYMedulla84.8359756469727100.0
380684OLFOlfactory bulb50.228397369384860.6290416717529
380684PPons77.1947212219238100.0
380684PALPallidum59.49840545654396.1248626708984
380684RHPRetrohippocampal region60.10727119445871.0239582061768
380684sAMYStriatum-like amygdalar nuclei39.250978469848639.8391218185425
380684STRStriatum26.812118530273425.3283276557922
380684STRdStriatum dorsal region22.138520240783719.4510626792908
380684STRvStriatum ventral region26.471675872802727.8763666152954
380684THThalamus100.0100.0
KARG Evidence 5
KARG ID:QTL0173
Trait:differences in cocaine responsiveness
Peak:5
Peak Marker:D11M!t2
Parents:C57BL/6J x DBA/2J intercross
Evidence ID:7932176
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4744GO:0000786IEAComponentnucleosome
4744GO:0003677IEAFunctionDNA binding
4744GO:0005198IEAFunctionstructural molecule activity
4744GO:0005554NDFunctionmolecular function unknown
4744GO:0005634IEAComponentnucleus
4744GO:0005883NASComponentneurofilament
4744GO:0006334IEAProcessnucleosome assembly
4744GO:0007399NASProcessnervous system development
4744GO:0030424TASComponentaxon
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6812NP_003156.1syntaxin binding protein 1 isoform aHPRD04235
NP_066554.16812-Syntaxin binding protein 1HPRD01204
NP_066554.15585NP_002732.1protein kinase C-like 1HPRD03019
NP_066554.15585NP_002732.1protein kinase C-like 1HPRD01204
NP_066554.14747NP_006149.1neurofilament, light polypeptide 68kDaHPRD01204
NP_066554.14747NP_006149.1neurofilament, light polypeptide 68kDaHPRD01206
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4744NFH_HUMANP12036IPR010790DUF1388Protein of unknown function DUF1388
4744NFH_HUMANP12036IPR005819Histone_H5Histone H5
4744NFH_HUMANP12036IPR001664IFIntermediate filament protein
4744NFH_HUMANP12036IPR002957Keratin_IKeratin, type I

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