Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4747
Official Symbol:NEFL
Other Aliases:CMT1F|CMT2E|NF-L|NF68|NFL
See related:HGNC:7739|MIM:162280|HPRD:01206
Chromosome:8
Location:8p21
Gene Description:neurofilament, light polypeptide 68kDa
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0351
ORGANISM:human
Entrez Gene ID:4747
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:18039
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0591
ORGANISM:human
Entrez Gene ID:4747
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:83613
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:EVIM0104
ORGANISM:human
Entrez Gene ID:4747
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:2.39 :: 3.70 :: 5.37 :: 3.42 :: -3.87 :: -2.78 :: -4.64
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4747GO:0005198IEAFunctionstructural molecule activity
4747GO:0005200TASFunctionstructural constituent of cytoskeleton
4747GO:0005515IPIFunctionprotein binding
4747GO:0005882IEAComponentintermediate filament
4747GO:0005883TASComponentneurofilament
4747GO:0030424IDAComponentaxon
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6709NP_003118.1spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)HPRD01684
NP_006149.16709-SpectrinHPRD01206
NP_006149.129117AAF19526.1Homo sapiens bromodomain protein CELTIX1 mRNA, complete cds.HPRD12531
NP_006149.17248NP_000359.1tuberous sclerosis 1 protein isoform 1HPRD05594
NP_006149.17248NP_000359.1tuberous sclerosis 1 protein isoform 1HPRD01206
NP_006149.17248NP_000359.1tuberous sclerosis 1 protein isoform 1BIND24868
NP_006149.15585NP_002732.1protein kinase C-like 1HPRD03019
NP_006149.15585NP_002732.1protein kinase C-like 1HPRD01206
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4747NFL_HUMANP07196IPR006821filament_DNA_bdIntermediate filament, DNA-binding region
4747NFL_HUMANP07196IPR001664IFIntermediate filament protein
4747NFL_HUMANP07196IPR003054Keratin_IIType II keratin
4747NFL_HUMANP07196IPR000533TropomyosinTropomyosin

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