Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4753
Official Symbol:NELL2
Other Aliases:NRP2
See related:HGNC:7751|MIM:602320|HPRD:11891
Chromosome:12
Location:12q13.11-q13.12
Gene Description:NEL-like 2 (chicken)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0126
ORGANISM:human
Entrez Gene ID:4753
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:54003
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0891
ORGANISM:human
Entrez Gene ID:4753
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.6 :: 1.6 :: -1.2 :: 1.6
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
54003CBCerebellum96.9784317016602100.0
54003CTXCerebral cortex100.0100.0
54003HIPHippocampal region100.0100.0
54003HPFHippocampal formation100.0100.0
54003HYHypothalamus95.0609130859375100.0
54003LSXLateral septal complex76.936441421508893.3679695129395
54003MBMidbrain94.7893333435059100.0
54003MYMedulla57.6601562593.2167778015137
54003OLFOlfactory bulb100.0100.0
54003PPons68.467910766601697.1335372924805
54003PALPallidum60.664329528808687.7085151672363
54003RHPRetrohippocampal region100.0100.0
54003sAMYStriatum-like amygdalar nuclei100.0100.0
54003STRStriatum100.0100.0
54003STRdStriatum dorsal region100.0100.0
54003STRvStriatum ventral region100.0100.0
54003THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4753GO:0005198NASFunctionstructural molecule activity
4753GO:0005509NASFunctioncalcium ion binding
4753GO:0005576NASComponentextracellular region
4753GO:0007155NASProcesscell adhesion
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4753NELL2_HUMANQ99435IPR000152Asx_hydroxyl_SAspartic acid and asparagine hydroxylation site
4753NELL2_HUMANQ99435IPR000742EGF_3EGF-like, type 3
4753NELL2_HUMANQ99435IPR001881EGF_Ca_bdEGF-like calcium-binding
4753NELL2_HUMANQ99435IPR013091EGF_Ca_bd_2EGF calcium-binding
4753NELL2_HUMANQ99435IPR013111EGF_extracellEGF, extracellular
4753NELL2_HUMANQ99435IPR006209EGF_likeEGF-like
4753NELL2_HUMANQ99435IPR013032EGF_like_regEGF-like region
4753NELL2_HUMANQ99435IPR012680Laminin_G_2Laminin G, subdomain 2
4753NELL2_HUMANQ99435IPR001491ThrmbomodulnThrombomodulin
4753NELL2_HUMANQ99435IPR001007VWF_Cvon Willebrand factor, type C

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